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Cleveland Clinic Performs First-In-World Full Multi-Organ Transplant to Treat Rare Appendix Cancer

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#USA, August 13, 2022 – Cleveland Clinic has successfully performed a first-in-the-world full multi-organ transplant to treat a patient with a rare form of appendix cancer called pseudomyxoma peritonei (PMP). Upon completion of the lifesaving transplant surgery, the patient received five digestive organs: liver, stomach, pancreas, duodenum, and small intestine.

Anil Vaidya, M.D., Cleveland Clinic’s Intestinal Transplant Program co-director, led the seven-surgeon team that completed the pioneering operation on a 32-year-old man in September 2021.

“The patient had one of the more advanced cases of PMP I have seen,” said Dr. Vaidya. “While about 80% of patients with the condition can be treated with traditional therapies, what do you do with the 20% for whom the traditional therapy isn’t successful? In some cases, the answer may be a multi-organ transplant.”

During the 17-hour operation, surgeons removed the patient’s diseased organs. He then received the following deceased donor’s organs all together and at the same time: liver, stomach, pancreas and duodenum (pancreaticoduodenal complex), spleen, small intestine, and right colon. The donor spleen was initially transplanted to boost the immune protection of the newly transplanted organs and improve blood flow to the pancreas until fully transplanted. The donor right colon was initially transplanted to help protect the new intestine from infection and improve its ability to absorb nutrients.  Both the donor spleen and donor right colon were removed prior to the completion of the transplant after they successfully served to protect the other organs during the operation.

“As far as we know, it is the first time in the world that a full multi-organ transplant, including the liver and four other digestive organs, is performed to treat PMP,” said Dr. Vaidya.

Prior to joining Cleveland Clinic in 2020, Dr. Vaidya performed in England the world’s first modified multi-organ transplant (excluding the liver) to treat a patient with PMP who had exhausted all other management strategies.

PMP is a rare cancer that typically originates as a tumor in the appendix. When the slow-growing tumor ruptures, its jelly-like content spreads to other digestive organs, with additional tumors developing that impair gastrointestinal function. Malnutrition and life-threatening complications ultimately occur.

Following the diagnosis in 2019, the patient began a long odyssey of treatments. He was one of the 20% of patients with PMP for whom the traditional treatments were ineffective. Often, this population of patients is left with few to no treatment options.

The patient was referred to Cleveland Clinic in 2021 in the end stage of his disease. He was receiving hospice care at that time. The patient had stopped working and could no longer eat solid foods. He was receiving nutrients intravenously through total parenteral nutrition (TPN).

“We needed to perform an evaluation to determine if transplantation in his case was safe, feasible and could provide long-term benefits,” said Dr. Vaidya.

Dr. Vaidya completed a thorough assessment of the patient’s case and received approval from Cleveland Clinic’s Intestinal Transplant Selection Committee to proceed. The patient was placed on the national transplant waiting list in July 2021.

“The patient – who needed a liver and four other digestive organs – had started to deteriorate quite rapidly,” said Dr. Vaidya. “It was touch-and-go that he would make it.”

In September 2021, a donor was found, and less than 24 hours later, the patient was undergoing the groundbreaking

surgery. The first three hours were preparatory, in essence removing the diseased abdominal organs. Next, the donor organs were inserted into the abdominal cavity, all the necessary vascular connections were completed and a left-sided ileostomy was created to handle bodily waste and let the body recover from the surgery.

“The operation was well planned and went like clockwork,” said Dr. Vaidya. “The team members knew exactly what they were going to do, and the timing was perfect. It went really well.”

Following the transplant, the patient remained in the hospital for 51 days.  Soon after he was discharged, he returned because he was suffering from a case of graft-versus-host disease, a common occurrence following intestinal or bone marrow transplants where the donated organs’ immune cells recognize the recipient’s tissues as foreign and attack the recipient.

The patient underwent a procedure perfected and performed by Amy Lightner, M.D., colorectal surgeon and director of Cleveland Clinic’s Center for Regenerative Medicine and Surgery. Dr. Lightner administered three doses of mesenchymal stromal cell (MSC)-derived exosomes, a first ever, novel treatment in solid organ transplants — another first for a patient who received a full multi-organ transplant to treat PMP.

According to Dr. Vaidya, “The patient’s recovery was absolutely amazing. His symptoms abated within two hours of the first dose.”

Nine months post-transplant, the patient, now 33, can eat and digest solid foods again and has energy to do what he loves, including walking and biking outdoors.

“There is currently no evidence of cancer recurrence,” said Dr. Vaidya.

 

Photo Captions: 

Header: Masato Fujiki, MD, (center) and the Cleveland Clinic surgical team, led by Anil Vaidya, MD, performing the first-in-world multi-organ transplant to treat a rare type of appendix cancer. (Photo courtesy of Cleveland Clinic)

1st insert: Anil Vaidya, M.D.

2nd insert: From left: Anil Vaidya, M.D., Shannon Jarancik, physician assistant, Amy Lightner, M.D., Andy Voge, patient, Rachel Voge, Andy’s wife, and Anita Barnoski, transplant coordinator.

Release: Cleveland Clinic / DPA media

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What to Look for with Self-Checks at Home

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February is National Self- Check Month and family medicine physician at Cleveland Clinic, OH, John Hanicak, MD, highlights why at home self-checks are extremely important when it comes to not just early cancer detection but identifying other illnesses too and offers tips on what to look out for.

“Sometimes Ilook at them as sort of like your check engine light on the car, just like therewould be a red flashing light that tells you that there’s something wrong with acar and prompts you to bring that in and get serviced. Your body does the samething. It gives you warning signs tolook intothat symptom a little bit further,” said Hanicak.

Dr. Hanicak saidself-checks are going to be a little different for everyone. 

However, in general, he recommends looking for anything that may seem abnormal, such asunexplained weight loss,blood in your urine, bumps and bruisesthat won’t heal,and changes in bowel habits. 

For example, if you suddenly start going to the bathroom a lot more than you used to, that could bea signof something more serious. 

He also suggestsdoing regular skin checksanddocumentingany molesor spotsthat start to look different. 

“Realize that you are your own person.There’s nobody else in the world exactly like you.You’ve got your own set ofideas, your own family history and your own genetics.Know what is normal for you, and when that changes, that’s the kind of thing thatwe would be interested in talking about,” said Dr. Hanicak. 

Dr. Hanicaknotes that self-checks are not meant to replace cancer screenings, as those are just as important to keep up with. 

Press Release: Cleveland Clinic

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Bruce Willis’ Brave Gift to Dementia Research – And His now Quiet Link to Turks & Caicos

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December 4, 2025 – Hollywood legend Bruce Willis – arguably the most famous former home owner in Turks and Caicos Islands – is facing the most difficult role of his life and turning it into one last act of service.

Willis, 70, retired from acting in 2022 after his family revealed he had been diagnosed with aphasia. The following year, specialists confirmed he is living with frontotemporal dementia (FTD), a degenerative brain disease that attacks language, behaviour and personality.

In recent interviews and appearances, his wife Emma Heming Willis has said Bruce is “surrounded by love and care” and that the family is learning to find joy in new ways, even as the disease progresses.

Now, Heming Willis has gone further.  In her 2025 memoir The Unexpected Journey, she writes that the family has decided Bruce’s brain will be donated to science after his death to advance research into FTD.  That decision has been highlighted in recent coverage by futurist and science outlets, which describe it as a carefully considered step after months of watching a still-physically-strong man steadily lose speech, reading and independence.

Neurologists have long stressed how rare donated brain tissue is for FTD, and how essential it is to understanding which proteins, mutations and mechanisms are actually driving the disease.  The Willis family’s choice means the brain that powered some of cinema’s most iconic characters could one day help researchers diagnose the condition earlier and design better treatments – even if it cannot help Bruce himself.

For Turks and Caicos, the story lands close to home.  For nearly two decades Willis owned “The Residence” on exclusive Parrot Cay – a 7.3-acre, Asian-inspired beachfront compound with a five-bedroom main house, two guest villas and a yoga pavilion.  He and Emma listed the estate in March 2019 for US$33 million; it sold a few months later for about US$27 million, one of the biggest residential deals in TCI history.

So, while Bruce Willis no longer has a physical address in Turks and Caicos, his connection to these islands remains part of his global story – a story now shifting from blockbuster fame to medical legacy, as his family turns private heartbreak into a public contribution that could change what we know about dementia.

Developed by Deandrea Hamilton • with ChatGPT (AI) • edited by Magnetic Media.

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From 54 New Cases in July to Zero in August: TCI’s COVID Turnaround

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Deandrea Hamilton | Editor

Turks and Caicos, September 6, 2025 – COVID-19 fears in the Turks and Caicos Islands that once had residents on edge are now giving way to a sense of relief. The Ministry of Health and Human Services reports a dramatic reversal: from dozens of new cases in July to zero cases and zero hospitalizations today.

Between August 17 and 23, 2025, officials confirmed no new cases, no hospitalizations, and no new deaths. Just two recoveries were recorded, bringing the national recovery tally to 6,866. The total confirmed cases since 2020 stand at 6,922, with deaths unchanged at 41. Health officials say August has been relatively quiet overall, with 19 new cases and recoveries recorded for the month — a fraction of what the islands faced just weeks earlier.

The contrast could not be sharper. The most concerning bulletin came in mid-July, when the Ministry reported 54 new cases in a single week. Ten were fresh positives, while the other 44 came from a backlog of April samples. At that time, two new hospitalizations were recorded, and the islands mourned one additional COVID-related death, bringing the total to 41. It was a sobering reminder that the virus was still circulating, pushing recoveries to 6,845 and raising the cumulative case count to 6,910. The July spike stirred fear among residents and renewed calls for vigilance, as community spread and delayed lab results painted a worrying picture.

Fast forward to late August, and the numbers tell a very different story. Not only are new cases negligible, but the hospitals are reporting no COVID-19 patients at all. Officials say testing continues across a wide range of categories, and the Ministry urges the public to stay cautious: wash hands, wear masks in crowded spaces, protect the vulnerable, and get vaccinated. But the tone now is one of optimism.

Since the pandemic began in 2020, Turks and Caicos has recorded nearly 7,000 cases in total, with 6,866 recoveries and 41 deaths. The islands’ small population means every case has felt significant, and surges like July’s were especially unsettling. But today’s figures suggest the country has reached a new stage: COVID-19 is no longer the disruptive force it was. The Ministry credits continued public vigilance and the accessibility of free testing and vaccines at government clinics. While the numbers are cause for celebration, health leaders are careful not to declare the fight over. The Ministry’s latest bulletin reminds residents to maintain hygienic practices, follow self-isolation guidelines if infected, and ensure vaccinations are up to date.

The pandemic may not be entirely behind the Turks and Caicos, but compared to the frightening figures of July, the near-zero landscape of August offers a powerful sign of hope.

The Ministry released the bulletin on September 2, confirming that for the week of August 17–23, no new cases, hospitalizations, or deaths were recorded — a sharp contrast to the surge just weeks earlier.

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