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Cleveland Clinic Performs First-In-World Full Multi-Organ Transplant to Treat Rare Appendix Cancer

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#USA, August 13, 2022 – Cleveland Clinic has successfully performed a first-in-the-world full multi-organ transplant to treat a patient with a rare form of appendix cancer called pseudomyxoma peritonei (PMP). Upon completion of the lifesaving transplant surgery, the patient received five digestive organs: liver, stomach, pancreas, duodenum, and small intestine.

Anil Vaidya, M.D., Cleveland Clinic’s Intestinal Transplant Program co-director, led the seven-surgeon team that completed the pioneering operation on a 32-year-old man in September 2021.

“The patient had one of the more advanced cases of PMP I have seen,” said Dr. Vaidya. “While about 80% of patients with the condition can be treated with traditional therapies, what do you do with the 20% for whom the traditional therapy isn’t successful? In some cases, the answer may be a multi-organ transplant.”

During the 17-hour operation, surgeons removed the patient’s diseased organs. He then received the following deceased donor’s organs all together and at the same time: liver, stomach, pancreas and duodenum (pancreaticoduodenal complex), spleen, small intestine, and right colon. The donor spleen was initially transplanted to boost the immune protection of the newly transplanted organs and improve blood flow to the pancreas until fully transplanted. The donor right colon was initially transplanted to help protect the new intestine from infection and improve its ability to absorb nutrients.  Both the donor spleen and donor right colon were removed prior to the completion of the transplant after they successfully served to protect the other organs during the operation.

“As far as we know, it is the first time in the world that a full multi-organ transplant, including the liver and four other digestive organs, is performed to treat PMP,” said Dr. Vaidya.

Prior to joining Cleveland Clinic in 2020, Dr. Vaidya performed in England the world’s first modified multi-organ transplant (excluding the liver) to treat a patient with PMP who had exhausted all other management strategies.

PMP is a rare cancer that typically originates as a tumor in the appendix. When the slow-growing tumor ruptures, its jelly-like content spreads to other digestive organs, with additional tumors developing that impair gastrointestinal function. Malnutrition and life-threatening complications ultimately occur.

Following the diagnosis in 2019, the patient began a long odyssey of treatments. He was one of the 20% of patients with PMP for whom the traditional treatments were ineffective. Often, this population of patients is left with few to no treatment options.

The patient was referred to Cleveland Clinic in 2021 in the end stage of his disease. He was receiving hospice care at that time. The patient had stopped working and could no longer eat solid foods. He was receiving nutrients intravenously through total parenteral nutrition (TPN).

“We needed to perform an evaluation to determine if transplantation in his case was safe, feasible and could provide long-term benefits,” said Dr. Vaidya.

Dr. Vaidya completed a thorough assessment of the patient’s case and received approval from Cleveland Clinic’s Intestinal Transplant Selection Committee to proceed. The patient was placed on the national transplant waiting list in July 2021.

“The patient – who needed a liver and four other digestive organs – had started to deteriorate quite rapidly,” said Dr. Vaidya. “It was touch-and-go that he would make it.”

In September 2021, a donor was found, and less than 24 hours later, the patient was undergoing the groundbreaking

surgery. The first three hours were preparatory, in essence removing the diseased abdominal organs. Next, the donor organs were inserted into the abdominal cavity, all the necessary vascular connections were completed and a left-sided ileostomy was created to handle bodily waste and let the body recover from the surgery.

“The operation was well planned and went like clockwork,” said Dr. Vaidya. “The team members knew exactly what they were going to do, and the timing was perfect. It went really well.”

Following the transplant, the patient remained in the hospital for 51 days.  Soon after he was discharged, he returned because he was suffering from a case of graft-versus-host disease, a common occurrence following intestinal or bone marrow transplants where the donated organs’ immune cells recognize the recipient’s tissues as foreign and attack the recipient.

The patient underwent a procedure perfected and performed by Amy Lightner, M.D., colorectal surgeon and director of Cleveland Clinic’s Center for Regenerative Medicine and Surgery. Dr. Lightner administered three doses of mesenchymal stromal cell (MSC)-derived exosomes, a first ever, novel treatment in solid organ transplants — another first for a patient who received a full multi-organ transplant to treat PMP.

According to Dr. Vaidya, “The patient’s recovery was absolutely amazing. His symptoms abated within two hours of the first dose.”

Nine months post-transplant, the patient, now 33, can eat and digest solid foods again and has energy to do what he loves, including walking and biking outdoors.

“There is currently no evidence of cancer recurrence,” said Dr. Vaidya.

 

Photo Captions: 

Header: Masato Fujiki, MD, (center) and the Cleveland Clinic surgical team, led by Anil Vaidya, MD, performing the first-in-world multi-organ transplant to treat a rare type of appendix cancer. (Photo courtesy of Cleveland Clinic)

1st insert: Anil Vaidya, M.D.

2nd insert: From left: Anil Vaidya, M.D., Shannon Jarancik, physician assistant, Amy Lightner, M.D., Andy Voge, patient, Rachel Voge, Andy’s wife, and Anita Barnoski, transplant coordinator.

Release: Cleveland Clinic / DPA media

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Health

Grand Turk Residents Fear Norovirus-Linked Cruise as Health Ministry Approves Docking

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Turks and Caicos, May 22, 2026 – Residents in Grand Turk raised concerns last week after a cruise ship previously linked to a major norovirus outbreak was cleared to dock in the Turks and Caicos Islands days after passengers were reportedly denied disembarkation in The Bahamas over health fears.

According to the US Centers for Disease Control and Prevention, the outbreak sickened 115 people — including 102 passengers and 13 crew members — during a voyage which ran from April 28 to May 11. The illnesses involved symptoms commonly associated with norovirus, including vomiting and diarrhea.

The outbreak became public on May 7 and quickly triggered concern across the region.

Authorities in Nassau reportedly refused to allow passengers off the vessel because of public health concerns connected to the outbreak.

That decision later fueled anxiety among some Turks and Caicos residents when the ship proceeded to Grand Turk on May 15.

Residents’ concerns were not without cause.

Norovirus is a highly contagious viral illness often associated with cruise ships, hotels, schools and other environments where large groups of people share close quarters. The virus primarily causes sudden vomiting, diarrhea, stomach cramps and nausea, and spreads rapidly through contaminated food, water, surfaces and person-to-person contact.

According to the US Centers for Disease Control and Prevention, most healthy people recover within one to three days, but norovirus can become serious — and occasionally fatal — for elderly individuals, young children and people with weakened immune systems because of severe dehydration. While the overall fatality rate is considered very low, the CDC estimates norovirus contributes to hundreds of deaths annually in the United States, mainly among vulnerable populations.

The Turks and Caicos Ministry of Health and Human Services had said in a press statement on May 15, it believed the risks had been effectively neutralized before the vessel arrived in Grand Turk.

In a statement issued Thursday, the Ministry said the ship had already returned to Florida, where passengers disembarked and “comprehensive sanitization and deep-cleaning procedures were completed” before operations resumed.

The Ministry also stressed that its Public Health Team maintained “close and continuous communication” with the ship’s medical personnel, Carnival Cruise Line officials and stakeholders at the Grand Turk Cruise Centre before approving the docking.

Routine inspections and standard port health procedures were also carried out, according to officials.

The Ministry further reassured the public that there were “currently no public health concerns” associated with the vessel’s arrival.

Still, the situation once again highlighted the delicate balancing act Caribbean nations face between protecting public health and sustaining tourism economies heavily dependent on cruise arrivals.

Officials are now encouraging vendors, taxi operators, tour companies and businesses to continue practicing strong sanitation and hygiene measures as an added precaution.

Residents were also reminded that frequent handwashing remains one of the most effective ways to prevent the spread of norovirus and other infectious illnesses.

Angle by Deandrea Hamilton. Built with ChatGPT (AI). Magnetic Media — CAPTURING LIFE.

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Health

29 Million Strong, the World Salutes Nurses as International Nurses Day is Observed

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On Tuesday May 12, the world pauses to honor one of humanity’s most trusted, exhausted, resilient and indispensable professions — nursing.

International Nurses Day is observed annually on the birthday of Florence Nightingale, widely regarded as the founder of modern nursing, and comes at a time when global healthcare systems continue to rely heavily on nurses carrying extraordinary emotional, physical and professional burdens.

According to the World Health Organization, there are an estimated 29 million nurses worldwide, making nursing the largest professional group within the global healthcare workforce. Yet despite their numbers, many countries continue to face severe nursing shortages, burnout crises and migration challenges as healthcare demands rise faster than staffing levels.

Still, nurses remain the heartbeat of healthcare.

They are present at life’s first breath and often its final moments. They work through hurricanes, pandemics, emergencies and violence. They calm fear, interpret pain, comfort families and frequently become the bridge between doctors, patients and hope itself.

In small island nations like those across the Caribbean, nurses often carry even greater responsibility — serving communities where resources may be stretched, specialists limited and healthcare systems under constant pressure.

This year’s observance again shines a spotlight not only on the compassion nurses bring to their profession, but also on the growing global call for better pay, safer working environments, improved mental health support and stronger investment in healthcare staffing.

For many people, the most memorable face in healthcare is not always the surgeon or specialist — it is the nurse who stayed a little longer, explained a little more gently or cared a little more deeply during a difficult moment.

Tomorrow’s observance is therefore more than ceremonial.

It is a reminder that behind every functioning hospital, clinic, emergency room, health center, operating theatre and recovery ward stands a nurse — often overworked, sometimes underappreciated, but consistently essential.

To nurses across The Bahamas, Turks and Caicos, the Caribbean and the wider world: thank you for showing up, even on the hardest days.

Developed by Deandrea Hamilton • with ChatGPT (AI) • edited by Magnetic Media.

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Government

$94.1Mfor Health; Knowles Pushes to Keep Care at Home

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Turks and Caicos, April 25, 2026 – A major shift in how healthcare is delivered in the Turks and Caicos Islands is at the center of the Government’s latest budget, with a focus on reducing reliance on overseas treatment and strengthening services at home.

Presenting his contribution to the national debate, Kyle Knowles outlined a strategy aimed at building a more sustainable healthcare system—one that allows more residents to access quality care within the country.

The health sector has been allocated $94.1 million, making it one of the largest areas of public spending in the $550.8 million Budget passed on April 23.

Central to the Minister’s approach is a restructuring of the Treatment Abroad Programme (TAP), which has grown significantly in recent years as more patients are sent overseas for specialized care.

The Government now aims to reverse that trend.

“We are reforming healthcare to ensure long-term sustainability,” Knowles indicated, pointing to efforts to strengthen local services and reduce the need for travel.

The strategy includes improving healthcare infrastructure, expanding services available within the islands and increasing efficiency through the digitization of medical records.

Digitization is expected to support better coordination of care, reduce delays and allow for more accurate tracking of patient needs—part of a broader effort to modernize public services.

The Minister emphasized that the goal is not only cost control, but improved access.

“No family should have to leave home to get quality care,” he said, underscoring the Government’s intention to refocus healthcare delivery on local capacity.

The shift comes as rising healthcare costs continue to place pressure on public finances, with overseas treatment representing one of the most expensive components of the system.

By investing more heavily in domestic services, the Government is seeking to reduce that burden while improving outcomes for residents.

While the direction is clear, details on timelines and the pace of expansion for local services were not fully outlined in the presentation.

Still, the emphasis on sustainability, access and modernization signals a strategic pivot in how healthcare is expected to evolve in the Turks and Caicos Islands.

Angle by Deandrea Hamilton. Built with ChatGPT (AI). Magnetic Media — CAPTURING LIFE.

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