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Cleveland Clinic Launches First-of-its Kind Preventive Breast Cancer Vaccine Study

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#October 30, 2021 – Cleveland Clinic researchers have opened a novel study for a vaccine aimed at eventually preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

This phase I trial is designed to determine the maximum tolerated dose of the vaccine in patients with early-stage triple-negative breast cancer and to characterize and optimize the body’s immune response. The U.S. Food and Drug Administration recently approved an investigational new drug application for the vaccine, which permits Cleveland Clinic and partner Anixa Biosciences, Inc. (ANIX:NASDAQ) to start the study.

“We are hopeful that this research will lead to more advanced trials to determine the effectiveness of the vaccine against this highly aggressive type of breast cancer,” said G. Thomas Budd, M.D., of Cleveland Clinic’s Taussig Cancer Institute and principal investigator of the study. “Long term, we are hoping that this can be a true preventive vaccine that would be administered to healthy women to prevent them from developing triple-negative breast cancer, the form of breast cancer for which we have the least effective treatments.”

There is a great need for improved treatments for triple-negative breast cancer, which does not have biological characteristics that typically respond to hormonal or targeted therapies. Despite representing only about 12-15% of all breast cancers, triple-negative breast cancer accounts for a disproportionately higher percentage of breast cancer deaths and has a higher rate of recurrence. This form of breast cancer is twice as likely to occur in African-American women, and approximately 70% to 80% of the breast tumors that occur in women with mutations in the BRCA1 genes are triple-negative breast cancer.

“This vaccine approach represents a potential new way to control breast cancer,” said Vincent Tuohy, Ph.D., the primary inventor of the vaccine and staff immunologist at Cleveland Clinic’s Lerner Research Institute. “The long-term objective of this research is to determine if this vaccine can prevent breast cancer before it occurs, particularly the more aggressive forms of this disease that predominate in high-risk women.” Dr. Tuohy is named as inventor on the technology, which Cleveland Clinic exclusively licensed to Anixa Biosciences, Inc. He will receive a portion of commercialization revenues received by Cleveland Clinic for this technology and also holds personal equity in the company.

The investigational vaccine targets a breast-specific lactation protein, α-lactalbumin, which is no longer found post-lactation in normal, aging tissues but is present in the majority of triple-negative breast cancers. Activating the immune system against this “retired” protein provides pre-emptive immune protection against emerging breast tumors that express α-lactalbumin. The vaccine also contains an adjuvant that activates an innate immune response that allows the immune system to mount a response against emerging tumors to prevent them from growing.

The study is based on pre-clinical research led by Dr. Tuohy that showed that activating the immune system against the α-lactalbumin protein was safe and effective in preventing breast tumors in mice. The research also found that a single vaccination could prevent breast tumors from occurring in mouse models, while also inhibiting the growth of already existing breast tumors. The research, originally published in Nature Medicine, was funded in part by philanthropic gifts from more than 20,000 people over the last 12 years.

Funded by the U.S. Department of Defense, the new study at Cleveland Clinic will include 18 to 24 patients who have completed treatment for early-stage triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence. During the course of the study, participants will receive three vaccinations, each two weeks apart and will be closely monitored for side effects and immune response. The study is estimated to be completed in September 2022.

Researchers anticipate that a subsequent trial will involve healthy, cancer-free women at high risk for developing breast cancer who have decided to undergo voluntary bilateral mastectomy to lower their risk. Typically, those women carry mutations in either the BRCA1 or BRCA2 gene and are therefore at risk of developing triple-negative breast cancer or have high familial risk for any form of breast cancer.

“This vaccine strategy has the potential to be applied to other tumor types,” added Dr. Tuohy. “Our translational research program focuses on developing vaccines that prevent diseases we confront with age, like breast, ovarian and endometrial cancers. If successful, these vaccines have the potential to transform the way we control adult-onset cancers and enhance life expectancy in a manner similar to the impact that the childhood vaccination program has had.”

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CIBC Caribbean Celebrates 2026 Unsung Heroes Finalists

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Nassau, Bahamas, 22 September 2026 – Six Bahamians whose service is making a difference in communities across the country were recently celebrated by CIBC Caribbean as the bank brought together its top 2026 Unsung Heroes finalists for a special recognition event.

The 2026 finalists were Kristin Butler-Beneby, Dinola Williamson, Amanda Knowles, Tamara Clarke, Ruth Fawkes, and Jaquay Adderley.

During the event, CIBC Caribbean also announced Dinola Williamson as the first runner-up in this year’s program. Williamson is an educator and community activist who has spent more than two decades in education and leads the Family Better Together Kabbalistic Kids Club. Her community work has reached children in Englerston, Fox Hill, Acklins, Crooked Island, and Grand Bahama through mentorship and activities designed to support their holistic development.

CIBC Caribbean Head of Country Terrance Gibson said the gathering was intentionally focused on celebrating the collective impact of the finalists.

“Unsung Heroes is about recognizing the people who may not always receive the spotlight, but whose commitment is felt every day in the lives of the people and communities they serve,” he said.

“While Kristin emerged as our 2026 Unsung Hero, and Dinola as our runner-up, each nominee represents the spirit of this program. They saw needs in their communities and made the decision to act, to serve, and to keep showing up. CIBC Caribbean is proud to recognize them and to help bring greater attention to the work they are doing.”

The recognition event also brought together members of the judging panel who reviewed this year’s nominations and selected the program’s honorees. The panel comprised Olympic gold medalist Tonique Williams, Bahamas Red Cross President Edison Sumner, Guardian Lifestyles Editor Shavaughn Moss, and Organization for Responsible Governance Executive Director Matt Aubry.

During the event, each finalist spoke about the community work that led to their nomination. The judges were also recognized for lending their time and expertise to the selection process.

Gibson added, “Recognition is important, but we also hope that sharing these stories encourages others to look around their own communities, see where they can make a difference, and act.

“Our Unsung Heroes remind us that meaningful change often begins with an individual who simply decides to help.”

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Public Hospitals Authority Foundation Donates Dialysis Machines to Princess Margaret Hospital (PMH)

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The Bahamas, September 21, 2026 – The Public Hospitals Authority (PHA) Foundation, a philanthropic organization launched in January 2024 to support public hospitals and healthcare clinics, donated eight additional dialysis machines for the PMH Renal Services unit.

Director of Foundations, Corporate and Community Relations for the Public Hospitals Authority and Executive Director of the foundation, Alana Major, said this initiative is a part of the foundation’s “Sun, Sea and Second Chances” campaign.  PHA Foundation aims to secure 30 machines for Princess Margaret Hospital.

“As of today, with this donation, we are now up to 15 machines, so we are very excited about that,” Ms. Major said.

Other members of the foundation were present, including PHA Foundation Chairman Mr. Selvin Basden, who said the foundation is committed to doing its part in fulfilling the mandate of the Government of the Bahamas.

“One of the tenets of the Government is to ensure that access to healthcare is a human right. We are committed to ensuring that, at least from our part, we can deliver on that principle,” Mr. Basden said.

The PMH Renal Services Unit dialyzes about 150 to 170 patients annually. The unit provides care for patients who have been diagnosed with end-stage kidney disease and now need renal support. Patients who receive dialysis typically come to the unit three times a week, either on a Monday-Wednesday-Friday schedule or a Tuesday-Thursday-Saturday schedule.

Head of Department for Renal Services, Dr. Thurston Carroll, said she and the unit are excited to receive the donation, as it will replace machines that are not operating optimally.

“We are particularly excited about today’s donation because, although we have 20 stations within the dialysis unit, we have an aging fleet. These new machines and new water-treatment equipment will allow us to replace some of our aging equipment so that we can continue providing services to our patients.”

Foundation representatives noted that one or two organizations are already considering making bulk donations and if it happens, the foundation may be able to secure another 10 machines or another five machines in the very near future.

PMH Deputy Hospital Administrator Angelica Lockhart-Bastian and Hospital Administrator Mr. Tevard Bastian thanked the PHA Foundation for its donation to Princess Margaret Hospital.

Also in attendance were PHA Foundation Deputy Chairman Dr. Erecia Hepburn; Foundation guest Dr. Maria Oriakhi; Chief Biomedical Engineer Mr. Theodore Nottage; Administrative Officer Ms. Appapisa Neely; and Senior Assistant Hospital Administrator Mr. Valdez Bowe.

 

By Christina Williams 
Bahamas Information Services

BIS Photos/Mark Ford

PHOTO CAPTION:

Group Photo, from left:
– Dr. Rhea Thurston Carroll, Director, Renal Services, PMH
– Nurse Kim Harris, Dialysis Nurse, Dialysis Unit, PMH
– ⁠Sister Darnell Roker, Nurse Manager, Dialysis Unit, PMH
– Mrs. Angelica Lockhart-Bastian, Deputy Hospital Administrator PMH
– Mr. Tevard Bastian, Hospital Administrator PMH
– Mrs. Alana Major, Director, Foundations, Community and Corporate Relations, PHA
– ⁠Mr. Selvin Basden, Chairman, PHA Foundation
– ⁠Dr. Erecia Hepburn, PHA Foundation Board
– ⁠Ms. Donette Danvers, Executive Assistant, Foundations, Community and Corporate Relations, PHA

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Bahamas News

Romer Receives Regional Leadership Award

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Miami, Florida – Director of Aviation and Deputy Director General of Tourism, Dr. Kenneth Romer was presented with The 2025-2026 Infrastructure Leadership MVP Award, during the 10th Annual Caribbean Infrastructure Forum (CARIF) held in Miami September 15-16, 2026.

According to event organizers, New Energy Events, the MVP Leadership Award is the highest individual honor in the industry and is presented to an individual who has demonstrated exceptional, strategic and visionary leadership in advancing infrastructure in the Caribbean. Chosen by an independent jury of regional industry leaders, “The recipient is recognized for their sustained impact, influence across sectors, and dedication to driving meaningful progress in policy, investment, or project delivery”, said Event Organizers.

Romer becomes only the third person from the Region, and the first from The Bahamas to receive the Leadership MVP Award, joining last year’s winner The Honourable Mia Mottley, Prime Minister of Barbados.

Represented among the Conference Speakers and present at the Award Ceremony was Minister of Energy, Utilities and Aviation, The Honourable JoBeth Coleby-Davis, who said that, “This award amplifies The Bahamas Government’s commitment to executing a vision that sets the benchmark for infrastructural investments opportunities across our archipelago while supporting exemplary Bahamian leaders like Dr. Romer, who are steering the Caribbean toward more resilient, investable, and innovative infrastructure”.

“While this award is deemed an individual honor, it is a recognition of the Bahamas’ position as a respected regional leader and more so, a reflection of the incredible talent that resides within our small, but indomitable nation that continues to punch above its weight class as the world marks the manner of our bearing”, said Dr. Romer.

Dr. Romer has been instrumental in driving post-pandemic tourism recovery alongside the transformation of airports across the Family Islands through the Government’s landmark Family Islands Renaissance initiative. Under his leadership as Director of Aviation and Deputy Director General of Tourism, the sector has embraced a strategic, forward-looking approach focused on modernizing over 19 runways and terminals, strengthening safety and resilience, expanding international and regional connectivity, and leveraging public-private partnerships to deliver world-class facilities.

Dr. Romer’s work has helped translate the National Aviation Strategic Plan into tangible infrastructure projects that are creating new opportunities for tourism, investment, entrepreneurship and economic growth across the archipelago.

In 2025, he became the first person from the Caribbean and LATAM Region to be appointed to the Board of the International Association of Airports Executives.

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