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Cleveland Clinic Launches First-of-its Kind Preventive Breast Cancer Vaccine Study

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#October 30, 2021 – Cleveland Clinic researchers have opened a novel study for a vaccine aimed at eventually preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

This phase I trial is designed to determine the maximum tolerated dose of the vaccine in patients with early-stage triple-negative breast cancer and to characterize and optimize the body’s immune response. The U.S. Food and Drug Administration recently approved an investigational new drug application for the vaccine, which permits Cleveland Clinic and partner Anixa Biosciences, Inc. (ANIX:NASDAQ) to start the study.

“We are hopeful that this research will lead to more advanced trials to determine the effectiveness of the vaccine against this highly aggressive type of breast cancer,” said G. Thomas Budd, M.D., of Cleveland Clinic’s Taussig Cancer Institute and principal investigator of the study. “Long term, we are hoping that this can be a true preventive vaccine that would be administered to healthy women to prevent them from developing triple-negative breast cancer, the form of breast cancer for which we have the least effective treatments.”

There is a great need for improved treatments for triple-negative breast cancer, which does not have biological characteristics that typically respond to hormonal or targeted therapies. Despite representing only about 12-15% of all breast cancers, triple-negative breast cancer accounts for a disproportionately higher percentage of breast cancer deaths and has a higher rate of recurrence. This form of breast cancer is twice as likely to occur in African-American women, and approximately 70% to 80% of the breast tumors that occur in women with mutations in the BRCA1 genes are triple-negative breast cancer.

“This vaccine approach represents a potential new way to control breast cancer,” said Vincent Tuohy, Ph.D., the primary inventor of the vaccine and staff immunologist at Cleveland Clinic’s Lerner Research Institute. “The long-term objective of this research is to determine if this vaccine can prevent breast cancer before it occurs, particularly the more aggressive forms of this disease that predominate in high-risk women.” Dr. Tuohy is named as inventor on the technology, which Cleveland Clinic exclusively licensed to Anixa Biosciences, Inc. He will receive a portion of commercialization revenues received by Cleveland Clinic for this technology and also holds personal equity in the company.

The investigational vaccine targets a breast-specific lactation protein, α-lactalbumin, which is no longer found post-lactation in normal, aging tissues but is present in the majority of triple-negative breast cancers. Activating the immune system against this “retired” protein provides pre-emptive immune protection against emerging breast tumors that express α-lactalbumin. The vaccine also contains an adjuvant that activates an innate immune response that allows the immune system to mount a response against emerging tumors to prevent them from growing.

The study is based on pre-clinical research led by Dr. Tuohy that showed that activating the immune system against the α-lactalbumin protein was safe and effective in preventing breast tumors in mice. The research also found that a single vaccination could prevent breast tumors from occurring in mouse models, while also inhibiting the growth of already existing breast tumors. The research, originally published in Nature Medicine, was funded in part by philanthropic gifts from more than 20,000 people over the last 12 years.

Funded by the U.S. Department of Defense, the new study at Cleveland Clinic will include 18 to 24 patients who have completed treatment for early-stage triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence. During the course of the study, participants will receive three vaccinations, each two weeks apart and will be closely monitored for side effects and immune response. The study is estimated to be completed in September 2022.

Researchers anticipate that a subsequent trial will involve healthy, cancer-free women at high risk for developing breast cancer who have decided to undergo voluntary bilateral mastectomy to lower their risk. Typically, those women carry mutations in either the BRCA1 or BRCA2 gene and are therefore at risk of developing triple-negative breast cancer or have high familial risk for any form of breast cancer.

“This vaccine strategy has the potential to be applied to other tumor types,” added Dr. Tuohy. “Our translational research program focuses on developing vaccines that prevent diseases we confront with age, like breast, ovarian and endometrial cancers. If successful, these vaccines have the potential to transform the way we control adult-onset cancers and enhance life expectancy in a manner similar to the impact that the childhood vaccination program has had.”

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Monument Supports Hands for Hunger With Paradise Plates Debut  

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NASSAU, Bahamas — Caribbean Wines & Spirits (CWS), The Bahamas’ leading wine and spirits distributor, proudly supported Paradise Plates, Hands for Hunger annual fundraiser with a flavorful offering of its newest product, Monument Beverage Co.

Monument, which launched this July and is available across six major islands, made its Paradise Plates debut. Guests enjoyed three bold flavors: Peach Passion, Ginger-Lime and Melon Fizz as they socialized throughout the evening.

Monument brand ambassadors engaged guests with knowledge on the ready-to-drink beverage’s unique taste and look. Many attendees were delighted to learn that Monument is 100% Bahamian-made and owned and enjoyed seeing the various national landmarks on the packaging.

The booth was adorned with vibrant brand colors, striped arches, tropical florals and a photo worthy backdrop featuring Monument cans filled with florals cascading down the wall.

At the end of the event, the entire Monument inventory had finished, making Monument’s Paradise Plates debut a huge success.

For more details on Caribbean Wines & Spirits, new products and specials, visit www.cwsbahamas.com today.

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Schweppes ‘the Art of Mixology’ Dazzles at Paradise Plates with Nemiroff Vodka

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NASSAU, Bahamas — Schweppes, in collaboration with Nemiroff Vodka dazzled guests with handcrafted cocktails during Paradise Plates, Hands for Hunger’s annual fundraiser held at Atlantis’ Imperial Ballroom.

The evenings’ theme, 70’s: Paradise Disco, inspired bold and delicious sips from Schweppes and Nemiroff.  The beautiful disco themed Schweppes booth, adorned with LED signs, lush greenery and hanging black and gold metallic orbs shined throughout the room.

Schweppes’ brand representatives and mixologists dressed in chic 70’s speakeasy attire engaged attendees throughout the night. Guests enjoyed receiving knowledge of each product and experiencing the vibrant energy of brand representatives.

Nemiroff Vodka, which is locally distributed by Caribbean Wines and Spirits (CWS), The Bahamas’ premier wines and spirits distributor; offered a unique variety of vodkas which made the perfect blend with Schweppes. Guests enjoyed, Nemiroff’s Honey Pepper, De Luxe, Burning Pear, Wild Cranberry, and Bold Orange vodkas throughout the night.

Fan favorite cocktails of the night were: the Wild Cranberry Tonic and the Bold Orange Fizz.

Following a positive response at Paradise Plates, CWS is offering Nemiroff and Schweppes specials at local liquor stores for the entire month. With the purchase of any 1-liter Nemiroff vodka, enjoy a complimentary three-pack of Schweppes mixers, to recreate the magic of Schweppes and Nemiroff.

Cara Douglas-Adderley, Senior Marketing Director for Caribbean Bottling (CBC), local producers and distributors of Coca-Cola and Dasani products and CWS shared the inspiration behind the Schweppes and Nemiroff promotion.

“We are thrilled to have paired Schweppes and Nemiroff for Paradise Plates this year, creating a premium cocktail experience for guests. After receiving such positive feedback, we wanted to extend that experience to consumers at home. Throughout October, consumers can visit their favorite watering hole, buy any 1-liter Nemiroff bottle and receive a free three-pack of Schweppes.”

Caribbean Bottling Company is proud to offer Schweppes, Coca-Cola’s premier mixer in collaboration with Caribbean Wines & Spirits and Nemiroff Vodka at Paradise Plates in support of Hands for Hunger’s mission.

For more information on CBC’s philanthropic work, new products and specials, visits www.cbcbahamas.com today.

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Two Months On, The Bahamas Academy of Sciences Turns Fifty Years of Research into Action

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First peer-reviewed paper published, policy brief delivered to Minister Lightbourne, a seat at Climate Week, and a growing public audience for Bahamian science

 

NASSAU, The Bahamas, 7 October 2026 — Two months after putting fifty years of research on The Bahamas “on the record” at its first public event in July, The Bahamas Academy of Sciences (BAS) has been turning that evidence into action.

Since July, the Academy has published its first peer-reviewed paper, presented its findings to Government through a policy brief, taken Bahamian science to Climate Week in Nassau and New York, and launched a growing public conversation in which Bahamians can ask scientists questions and get answers. The Academy’s new policy brief, “Prioritising National Research Needs for The Bahamas,” is attached to this release.

“In July we said the record was open. Since then, we have been working to put it to use,” said BAS President Dr. Krista Sherman. “Fifty years of research revealed where The Bahamas is strong and where the gaps are: water, food, energy, long-term monitoring. Our job as the national academy is to share that evidence with the decision-makers and the public they serve, and to build the Bahamian research capacity to fill those gaps.”

THE RECORD, NOW PEER-REVIEWED AND PUBLIC

The Academy’s first publication, “Fifty Years of Research in The Commonwealth of The Bahamas: A Quantitative Thematic Analysis of Scholarly Output,” is now published in the international journal Gulf and Caribbean Research. Led by Dr. Amina Moss (University of Stirling) with BAS members Dr.

Krista Sherman, Dr. Williamson Gustave, Dr. Kathleen Sullivan Sealey, Dr. Charlotte Dunn, Dr. Nicola Smith, Lindy Knowles and Dr. Christy Gibson, the study analyses 12,113 scholarly records published about The Bahamas between 1975 and 2025.

It shows a rich scientific legacy, particularly in geology, fisheries, oceanography and conservation, while also highlighting persistent gaps in areas of direct national importance: groundwater resources, food systems, renewable energy, social-ecological governance and locally led, long-term monitoring. The full paper is free to read at https://doi.org/10.18785/gcr.3701.15.

FROM THE RECORD TO POLICY

Building on this research, BAS has prepared a policy brief, “Prioritising National Research Needs for The Bahamas,” which translates the findings into a set of ten strategic priorities.

The policy brief calls for greater investment in locally led, policy-aligned and climate-ready research, including:

  • a national research agenda aligned with Vision 2040;
  • stronger local scientific capacity, laboratories and field stations;
  • rebuilt long-term monitoring of reefs, fisheries, coasts and mangroves;
  • targeted research on groundwater, food systems and renewable energy;
  • a national environmental and health data repository; and public health research on the risks facing small island states.

In September, Dr. Sherman presented the brief to the Hon. Zane Lightbourne, Minister of the Environment and Natural Resources, during a courtesy call. The visit is the first in a series of introductory meetings with Government ministries over the coming months. Through these meetings, the Academy will introduce its work and explore opportunities for collaboration in science, the environment, sustainability, conservation and climate resilience. The policy brief also maps research priorities to relevant national legislation and policies, from the Environmental Planning and Protection Act to the National Health Strategy 2026–2030.

BAHAMIAN SCIENCE AT CLIMATE WEEK, FROM NASSAU TO NEW YORK

BAS also brought Bahamian scientific expertise to Climate Week 2026.

On Monday, 21 September, BAS Board member Dr. Kathleen Sullivan Sealey, Professor Emerita at the University of Miami, presented “Coasts and Climate Change” at the opening day of Climate Week in The Bahamas, hosted by the Baha Mar Resort Foundation at ECCHO, under the theme “At the Edge of the Water.” Dr. Sullivan Sealey explained why The Bahamas’ low-lying carbonate islands face growing risk from sea-level rise and storms, and how historical losses of coral reefs, seagrass, mangroves and dunes have weakened the islands’ natural defences. More importantly, she highlighted actions communities can take to reduce these risks.

During Climate Week, the Academy also released a science statement, “Climate Change and Ocean Warming Impacts on The Bahamas: What Does the Science Tell Us?”, a synthesis of the environmental, ecological, social and economic impacts facing the archipelago.

In New York, BAS Vice President Dr. Adelle Thomas, Vice-Chair of Working Group II of the Intergovernmental Panel on Climate Change (IPCC), brought the realities of vulnerable small island states to Climate Week NYC.

A GROWING PUBLIC AUDIENCE FOR BAHAMIAN SCIENCE

The Academy’s public campaign, 242 #ForTheRecord, has also been building a presence across its five platforms since launching in mid-July. Its most successful format has been the simplest: Bahamians ask a question and a BAS scientist answers it. So far, the “You Ask/Science Responds” series has tackled questions on how climate change will affect Bahamian farming (Dr. Williamson Gustave) and the science of blue holes (Dr. Krista Sherman). An upcoming episode will examine the effects of high temperatures on public health. Question-led content is reaching roughly twice the audience of the Academy’s institutional posts. During its first month, the campaign generated more than 18,500 views and over 200 shares across its platforms.

To extend the conversations to more Bahamians, beyond the traditional science-curious audiences,

BAS has also formalised collaborations with two local content creators, Kaché Knowles (“I is a Bahamian Bey”) and Stephen Hanna (“Schin Nguyen”). Their first joint pieces will appear before the campaign closes on 30 November.

WHAT COMES NEXT

For BAS, putting the record to work is only the beginning. Over the coming months, the Academy will:

  • continue introductory meetings with Government ministries and agencies;
  • host its Future Scientists classroom event with Bahamian students in early November;
  • launch its YouTube channel with a video-podcast series on Bahamian scientists in November;
  • begin work on its second peer-reviewed publication, “A Horizon Scan on Emerging Environmental Issues in The Bahamas Over the Next Decade”; and
  • offer “Introduction to Statistics using Excel,” a short, practical course in early 2027 that will give early-career scientists and resource managers in The Bahamas hands-on skills in organising, analysing and summarising their own data.

“Research is most valuable when it can be used,” said Dr. Sherman. “The Bahamas has an extraordinary scientific record. Now we need to ensure that record informs the questions we ask, the decisions we make, and the science we build here at home.”

See BAS Climate Statement and BAS Policy Briefing 50 Years of Bahamian Research here: BAS Climate Statement,

BAS Policy Briefing_50 Years of Bahamian Research

PHOTO CAPTIONS:

Header: BAS President Dr. Krista Sherman met the Minister of the Environment and Natural Resources and his team on 17 September 2026. L–R: Mr. David Davis, Permanent Secretary; Mr. Ricardo Deveaux, Acting Under Secretary; The Hon. S. Obie Roberts, Parliamentary Secretary; Dr. Krista Sherman, BAS President; The Hon. Zane Lightbourne, Minister; Dr. Rhianna Neely-Murphy, Director, Department of Environmental Planning and Protection; Ms. Danielle Hanek, Acting Director, Forestry Unit.

Credit: Ministry of Environment and Natural Resources.

Insert: Kathleen Sullivan Sealey, BAS Board member, presents the Academy’s science statement at Climate Week in The Bahamas, ECCHO, 21 September 2026.

Credit: Amaeleo Carey.

PRESS RELEASE: BAS

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