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Cleveland Clinic Launches First-of-its Kind Preventive Breast Cancer Vaccine Study

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#October 30, 2021 – Cleveland Clinic researchers have opened a novel study for a vaccine aimed at eventually preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

This phase I trial is designed to determine the maximum tolerated dose of the vaccine in patients with early-stage triple-negative breast cancer and to characterize and optimize the body’s immune response. The U.S. Food and Drug Administration recently approved an investigational new drug application for the vaccine, which permits Cleveland Clinic and partner Anixa Biosciences, Inc. (ANIX:NASDAQ) to start the study.

“We are hopeful that this research will lead to more advanced trials to determine the effectiveness of the vaccine against this highly aggressive type of breast cancer,” said G. Thomas Budd, M.D., of Cleveland Clinic’s Taussig Cancer Institute and principal investigator of the study. “Long term, we are hoping that this can be a true preventive vaccine that would be administered to healthy women to prevent them from developing triple-negative breast cancer, the form of breast cancer for which we have the least effective treatments.”

There is a great need for improved treatments for triple-negative breast cancer, which does not have biological characteristics that typically respond to hormonal or targeted therapies. Despite representing only about 12-15% of all breast cancers, triple-negative breast cancer accounts for a disproportionately higher percentage of breast cancer deaths and has a higher rate of recurrence. This form of breast cancer is twice as likely to occur in African-American women, and approximately 70% to 80% of the breast tumors that occur in women with mutations in the BRCA1 genes are triple-negative breast cancer.

“This vaccine approach represents a potential new way to control breast cancer,” said Vincent Tuohy, Ph.D., the primary inventor of the vaccine and staff immunologist at Cleveland Clinic’s Lerner Research Institute. “The long-term objective of this research is to determine if this vaccine can prevent breast cancer before it occurs, particularly the more aggressive forms of this disease that predominate in high-risk women.” Dr. Tuohy is named as inventor on the technology, which Cleveland Clinic exclusively licensed to Anixa Biosciences, Inc. He will receive a portion of commercialization revenues received by Cleveland Clinic for this technology and also holds personal equity in the company.

The investigational vaccine targets a breast-specific lactation protein, α-lactalbumin, which is no longer found post-lactation in normal, aging tissues but is present in the majority of triple-negative breast cancers. Activating the immune system against this “retired” protein provides pre-emptive immune protection against emerging breast tumors that express α-lactalbumin. The vaccine also contains an adjuvant that activates an innate immune response that allows the immune system to mount a response against emerging tumors to prevent them from growing.

The study is based on pre-clinical research led by Dr. Tuohy that showed that activating the immune system against the α-lactalbumin protein was safe and effective in preventing breast tumors in mice. The research also found that a single vaccination could prevent breast tumors from occurring in mouse models, while also inhibiting the growth of already existing breast tumors. The research, originally published in Nature Medicine, was funded in part by philanthropic gifts from more than 20,000 people over the last 12 years.

Funded by the U.S. Department of Defense, the new study at Cleveland Clinic will include 18 to 24 patients who have completed treatment for early-stage triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence. During the course of the study, participants will receive three vaccinations, each two weeks apart and will be closely monitored for side effects and immune response. The study is estimated to be completed in September 2022.

Researchers anticipate that a subsequent trial will involve healthy, cancer-free women at high risk for developing breast cancer who have decided to undergo voluntary bilateral mastectomy to lower their risk. Typically, those women carry mutations in either the BRCA1 or BRCA2 gene and are therefore at risk of developing triple-negative breast cancer or have high familial risk for any form of breast cancer.

“This vaccine strategy has the potential to be applied to other tumor types,” added Dr. Tuohy. “Our translational research program focuses on developing vaccines that prevent diseases we confront with age, like breast, ovarian and endometrial cancers. If successful, these vaccines have the potential to transform the way we control adult-onset cancers and enhance life expectancy in a manner similar to the impact that the childhood vaccination program has had.”

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PM Davis: Artificial Intelligence Micro-Course Graduation is ‘something very special’

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NASSAU, The Bahamas – During his Official Remarks at the University of The Bahamas-Partanna-King Abdullah University of Science and Technology (KAUST) Artificial Intelligence (AI) Intensive Micro-Course Graduation Ceremony, on May 22, 2024, Prime Minister and Minister of Finance the Hon. Philip Davis said that he believed that those involved had accomplished “something very special.”

“I see this as the start of what will hopefully be an ongoing initiative, as we embrace the power of strategic partnerships and innovative ideas that can empower our people for success,” he said, during the ceremony held at Choices Restaurant on UB Main Campus.

Among those present included UB Acting President Janyne Hodder; UB Provost and Vice-President of Academic Affairs Dr. Maria Woodside-Oriakhi; Dean of the UB College of Business Dr. Marlo Murphy-Braynen; UB Chair of the School of Business Daniel Thompson; Dr. Dematee Mohan of the Office of the Prime Minister; and Director-General of Bahamas Information Services Elcott Coleby.

A number of podium guests also assisted in presenting five micro-course graduates with scholarships to KAUST.

Prime Minister Davis stated that the world was currently going through an era of “rapid, and, I dare say, epic change.”

“They are calling it the triple transition, which includes climate change, demographic change, as well as digital change,” he noted.  “The Bahamas is experiencing each of these changes in profound ways.”

He added: “Climate change represents the biggest threat we have ever, ever faced, as well as the biggest opportunity to re-align our society with our values to make the world cleaner, healthier, more prosperous, and more just.  And then there is digital transformation, which requires tremendous investments in infrastructure, and, of course, education in digital skills so that our workforce can remain competitive in this new era.”

Prime Minister Davis pointed out that the impact of that global transition was so broad that embracing those changes as opportunities required the integration of climate resilience and digital innovation into every aspect of The Bahamas’ national development models.

“That is why I am so proud of what we have accomplished today,” he said.  “We have opened the eyes of these young Bahamian scholars to the vast world of digital transformation through AI and machine learning.”

“We have placed this great potential at their fingertips so that they can go on to be, not just consumers of digital technology, but also digital producers, disruptors, and innovators,” Prime Minister Davis added.

He pointed out that they lived in a time when AI had become commonplace. Universities, Prime Minister Davis added, were grappling with the ethical implications of natural language algorithms, like Chat GPT, which produced essays with just a few prompts.

“Programmers and writers are using open-source AI apps to become more efficient and productive,” he said.  “We are seeing the widespread application of AI in every sector that is redefining how we work.”

“The AI revolution has already made waves here in The Bahamas,” Prime Minister Davis added.  “Local businesses are using AI to collect data and empower their marketing initiatives.”

He continued:  “My administration has pioneered the use of AI at the Ministry of Tourism, where AI chatbots are facilitating more efficient customer service and AI algorithms are helping us to identify and target likely visitors.  Even the Water and Sewerage Corporation has begun using AI to detect leaks.

“But this is just the beginning.”

Prime Minister Davis said that AI was still in its infancy. In the near future, he added, AI will take over repetitive, everyday tasks in fields as vast as engineering, programming, law, accounting, marketing, and healthcare administration.

“We also anticipate using AI in our current efforts to fight climate change and make our nation more climate resilient,” Prime Minister Davis noted.  “With these changes, some current jobs may become obsolete, but new jobs within data science and AI will emerge.”

“We will need a robust supply of well-trained, well-educated professionals to ensure that The Bahamas continues to keep pace with global economic developments,” he added.  “And we want those professionals to be Bahamians.

“Today, we have taken steps toward building that future-focused workforce with 20 bright young scholars here at UB.”

Prime Minister Davis thanked KAUST, with special mention to Director Albarakati and Professor Khan for “partnering with us on this groundbreaking initiative.”

“I hope this is the beginning of a fruitful partnership that will enrich our students and allow for the exchange of knowledge between faculty to strengthen our institutions,” he said.

Prime Minister Davis also thanked Partanna, and its CEO, His Excellency, Ambassador Rick Fox, for helping to make the partnership happen through its funding and support.

“Thank you, as well, for your continued commitment to the environment through your groundbreaking carbon-negative concrete that will transform the global construction industry,” Prime Minister Davis said.

“Ambassador Fox, you are truly a proud son of our soil, and you continue to inspire us all,” he added.

Prime Minister thanked the faculty and staff at the University of The Bahamas for “their support in making this happen.”

“They often say if you can make it at UB, you can make it anywhere,” he pointed out.  “This saying has proven true, not just because of the academic integrity and rigour of UB’s programmes, but because of UB’s willingness to embrace change and opportunity.”

He added:  “Thank you to UB’s dynamic leadership team, President Hodder, UB’s Chair Mrs. Maynard Gibson, the Dean of the College of Business, Dr. Marlo Murphy Braynen, Dr. (Woodside-) Oriakhi and your team for making this possible.  Most importantly, thank you to the students who enrolled and committed to completing this course as an investment in your future and your future prospects.”

For those students who go on to continue their studies in AI, either at King Abdullah University or through other avenues, Prime Minister encouraged them to continue exploring their interests and talents.

“Continue adding in-demand skills to your repertoire and continue being trailblazers in your respective fields,” he said.  “Congratulations to all of you.”

“We will need bright, young leaders to take on the challenges that lay ahead of us,” Prime Minister Davis added.  “Based on what I am seeing today, I am confident that the future is in good, good hands.

“God bless you all and may He continue to bless our nation.”

PHOTO CAPTION

Prime Minister and Minister of Finance the Hon. Philip Davis takes part in the University of The Bahamas-Partanna-King Abdullah University of Science and Technology (KAUST) Artificial Intelligence (AI) Intensive Micro-Course Graduation Ceremony, on May 22, 2024, held at Choices Restaurant on UB Main Campus.  Among those present included UB Acting President Janyne Hodder; UB Provost and Vice President of Academic Affairs Dr. Maria Woodside-Oriakhi; Dean of the UB College of Business Dr. Marlo Murphy-Braynen; UB Chair of the School of Business Daniel Thompson; Dr. Dematee Mohan of the Office of the Prime Minister; and Director-General of Bahamas Information Services Elcott Coleby.  A number of podium guests also assisted in presenting five micro-course graduates with scholarships to KAUST.  (BIS Photos/Eric Rose)

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124 HAITIAN NATIONALS REPATRIATED TO CAP-HAITIEN, HAITI

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#TheBahamas, May 21, 2024 – On Wednesday, May 15, the Department effectively executed the repatriation of a group of illegal migrants from the Lynden Pindling International Airport, New Providence to Cap-Haitien, Haiti.

At approximately 9:11 a.m., a Bahamasair chartered flight departed New Providence en route to Haiti with one hundred twenty-four (124) Haitian nationals onboard; a hundred and eight (108) adult males, thirteen (13) adult females and three (3) minors. The Department’s Deportation and Enforcement Units led the escort.

All security and health protocols were observed as the safety and welfare of our officers, law enforcement counterparts and migrants remain the highest priority.

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Introducing The Bahamas Cannabis Authority; Marijuana Bill tabled by Darville

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Garfield Ekon

Staff Writer

 

#TheBahamas, May 20, 2024 – A medical marijuana industry is set for establishment in The Bahamas, following the tabling of the Cannabis Bill, 2024, in the House of Assembly, by Minister of Health and Wellness, Hon. Dr Michael Darville, May 15.

The Minister said objective of legislation is to set up a framework to establish The Bahamas Cannabis Authority, and to regulate the of importation, exportation, cultivation, processing, manufacturing, producing, sale, possession, distribution, and use of cannabis.

He told the Assembly that the law represents a thoughtful and balanced approach and was driven by a duty to act as he referenced the number of Bahamians who are battling cancer and in need of alternative treatments for pain management and other related issues.

“The legislative package, the Cannabis Bill, 2024 is designed to introduce a controlled system of cannabis use in medical treatments. The bill establishes the Bahamas Cannabis Authority.  A regulatory body overseeing all aspects of cannabis management and cultivation and distribution.  The authority’s mandate is to ensure that cannabis production and use are safe, controlled and effectively integrated into our health care system,” Minister Darville said.

Adding that the Dangerous Drugs (Amendment) Bill, 2023 that he also tabled, reclassifies cannabis by removing it from the dangerous drug list, now recognises its potential for medical use, he said the change aligns “our nations laws” with evolving global perspectives on cannabis.

The new law makes provisions for the licensing of cannabis handlers across various aspects of The Bahamas, and Dr. Darville said the licensing is structured to prioritise Bahamian ownership, with provisions ensuring that significant control remains in the hands of Bahamian nationals, fostering local entrepreneurship and economic benefits “for Bahamians across the country.

“We are here to make a difference, to enact change, remove years of stigma and transform lives by offering alternative treatments by way of medical cannabis.  The legislation before us offers a careful, considerate approach ensuring that we prioritize the wellbeing and safety of our citizens. Let us move with compassion,” he said.

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