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Cleveland Clinic Launches First-of-its Kind Preventive Breast Cancer Vaccine Study

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#October 30, 2021 – Cleveland Clinic researchers have opened a novel study for a vaccine aimed at eventually preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

This phase I trial is designed to determine the maximum tolerated dose of the vaccine in patients with early-stage triple-negative breast cancer and to characterize and optimize the body’s immune response. The U.S. Food and Drug Administration recently approved an investigational new drug application for the vaccine, which permits Cleveland Clinic and partner Anixa Biosciences, Inc. (ANIX:NASDAQ) to start the study.

“We are hopeful that this research will lead to more advanced trials to determine the effectiveness of the vaccine against this highly aggressive type of breast cancer,” said G. Thomas Budd, M.D., of Cleveland Clinic’s Taussig Cancer Institute and principal investigator of the study. “Long term, we are hoping that this can be a true preventive vaccine that would be administered to healthy women to prevent them from developing triple-negative breast cancer, the form of breast cancer for which we have the least effective treatments.”

There is a great need for improved treatments for triple-negative breast cancer, which does not have biological characteristics that typically respond to hormonal or targeted therapies. Despite representing only about 12-15% of all breast cancers, triple-negative breast cancer accounts for a disproportionately higher percentage of breast cancer deaths and has a higher rate of recurrence. This form of breast cancer is twice as likely to occur in African-American women, and approximately 70% to 80% of the breast tumors that occur in women with mutations in the BRCA1 genes are triple-negative breast cancer.

“This vaccine approach represents a potential new way to control breast cancer,” said Vincent Tuohy, Ph.D., the primary inventor of the vaccine and staff immunologist at Cleveland Clinic’s Lerner Research Institute. “The long-term objective of this research is to determine if this vaccine can prevent breast cancer before it occurs, particularly the more aggressive forms of this disease that predominate in high-risk women.” Dr. Tuohy is named as inventor on the technology, which Cleveland Clinic exclusively licensed to Anixa Biosciences, Inc. He will receive a portion of commercialization revenues received by Cleveland Clinic for this technology and also holds personal equity in the company.

The investigational vaccine targets a breast-specific lactation protein, α-lactalbumin, which is no longer found post-lactation in normal, aging tissues but is present in the majority of triple-negative breast cancers. Activating the immune system against this “retired” protein provides pre-emptive immune protection against emerging breast tumors that express α-lactalbumin. The vaccine also contains an adjuvant that activates an innate immune response that allows the immune system to mount a response against emerging tumors to prevent them from growing.

The study is based on pre-clinical research led by Dr. Tuohy that showed that activating the immune system against the α-lactalbumin protein was safe and effective in preventing breast tumors in mice. The research also found that a single vaccination could prevent breast tumors from occurring in mouse models, while also inhibiting the growth of already existing breast tumors. The research, originally published in Nature Medicine, was funded in part by philanthropic gifts from more than 20,000 people over the last 12 years.

Funded by the U.S. Department of Defense, the new study at Cleveland Clinic will include 18 to 24 patients who have completed treatment for early-stage triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence. During the course of the study, participants will receive three vaccinations, each two weeks apart and will be closely monitored for side effects and immune response. The study is estimated to be completed in September 2022.

Researchers anticipate that a subsequent trial will involve healthy, cancer-free women at high risk for developing breast cancer who have decided to undergo voluntary bilateral mastectomy to lower their risk. Typically, those women carry mutations in either the BRCA1 or BRCA2 gene and are therefore at risk of developing triple-negative breast cancer or have high familial risk for any form of breast cancer.

“This vaccine strategy has the potential to be applied to other tumor types,” added Dr. Tuohy. “Our translational research program focuses on developing vaccines that prevent diseases we confront with age, like breast, ovarian and endometrial cancers. If successful, these vaccines have the potential to transform the way we control adult-onset cancers and enhance life expectancy in a manner similar to the impact that the childhood vaccination program has had.”

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Dredging Is Not Just About Size — It Is About What Is Being Destroyed, Warns Save Exuma Alliance Regarding Yntegra’s Proposed Rosewood Resort

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Save Exuma Alliance (SEA) — a coalition of Central Exuma business owners, tour operators and residents — has warned that the issue of dredging in the North Bay of Sampson Cay, Exuma, is not just about the number of acres being dredged – but what exists within the proposed dredge area. SEA describes the site as an ecological treasure trove filled with seagrass, coral, turtles and abundant marine life.

This comes after foreign developer Yntegra agreed to reduce the scope of its dredging following government warnings that it would impact The Bahamas carbon credit status, which shows the importance of the marine habitat.

“It is easy to point to other developments and say they are dredging more, but that is not comparing like with like,” SEA said in response to comparisons made by Yntegra. “If one area is largely sand with little marine life, that is very different from what we have in North Bay. Anyone who has spent time there can tell you it is filled with turtles, fish, and — critically — the seagrass and coral that provide essential habitat.”

Miami-based investment group Yntegra is seeking to construct a large-scale Rosewood-branded resort on Sampson Cay. Since its announcement, the project has generated environmental, social and economic concerns among residents and business operators in Central Exuma.

The proposed development includes dredging in North Bay, construction of a substantial seawall that would alter natural water flow, more than 100 structures, two mega yacht marinas, and an industrial dock serviced by fuel and supply ships in an area currently used by swimmers. Opponents argue that the scale and design of Yntegra’s Rosewood Exuma project are incompatible with the fragile ecosystem and cultural character of the Central Exumas.

SEA noted that the government’s Climate Change Unit has also raised concerns about the environmental cost of dredging associated with Yntegra’s Rosewood Exuma project.

“The government has acknowledged that this is an area of significant importance,” SEA said. “While the financial implications are serious, for us here in Exuma this is about more than money. It underscores how valuable this marine ecosystem is — the seagrass, coral and marine life that make Exuma exceptional. This is what attracts visitors from around the world. We should not minimize the concern by comparing this bay to areas that do not have the same remarkable underwater ecosystem. It is simply not the same.”

Experienced boat captain Tito Baldwin also questioned the feasibility of the marine infrastructure proposed as part of this plan. He warned that the dredging currently outlined would not be sufficient to accommodate the vessels required to service the project.

“It’s going to have to be at least four times larger than what has been proposed,” Baldwin said. “As designed, it is beyond possibility.”

He explained that vessels supplying fuel, construction materials and provisions for a projected 300-person workforce would require significantly greater depth and maneuvering space.

“For supply vessels delivering hundreds of thousands of gallons of diesel, you’re looking at ships with a 10-foot draft,” Baldwin said. “To operate safely, you would need at least 13 feet of depth. That means dredging far deeper than what has been proposed. With currents running east and west in that area, you would also need a much wider turning basin to maneuver safely. As it stands, it would be extremely difficult, if not impossible.”

SEA is urging individuals concerned about the environmental impact of dredging connected to Yntegra’s Rosewood Exuma project to visit www.saveexumaalliance.org for more information. A petition calling for a halt to approvals is also available on the site, with more than 7,100 signatures collected to date.

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Groundbreaking for Grand Bahama Aquatic Centre

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PM: Project delivers on promise and invests in youth, sports and national development

 

GRAND BAHAMA, The Bahamas — Calling it the fulfillment of a major commitment to the island, Prime Minister Philip Davis led the official groundbreaking for the Grand Bahama Aquatic Centre, a facility the government says will transform sports development and create new opportunities for young athletes.

Speaking at the Grand Bahama Sports Complex on February 12, the Prime Minister said the project represents more than bricks and mortar — it is an investment in people, national pride and long-term economic activity.                                                                                                                                                    The planned complex will feature a modern 50-metre competition pool, designed to meet international standards for training and regional and global swim meets. Davis said the facility will give Bahamian swimmers a home capable of producing world-class performance while also providing a space for community recreation, learn-to-swim programmes and water safety training.

He noted that Grand Bahama has long produced outstanding athletes despite limited infrastructure and said the new centre is intended to correct that imbalance, positioning the island as a hub for aquatic sports and sports tourism.

The Prime Minister also linked the development to the broader national recovery and revitalisation of Grand Bahama, describing the project as part of a strategy to expand opportunities for young people, create jobs during construction and stimulate activity for small businesses once operational.

The Aquatic Centre, he said, stands as proof that promises made to Grand Bahama are being delivered.

The project is expected to support athlete development, attract competitions, and provide a safe, modern environment for residents to access swimming and water-based programmes for generations to come.

Angle by Deandrea Hamilton. Built with ChatGPT (AI). Magnetic Media — CAPTURING LIFE.

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Tens of Millions Announced – Where is the Development?

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The Bahamas, February 15, 2026 – For the better part of three years, Bahamians have been told that major Afreximbank financing would help transform access to capital, rebuild infrastructure and unlock economic growth across the islands. The headline figures are large. The signing ceremonies are high profile. The language is ambitious. What remains far harder to see is the measurable impact in the daily lives of the people those announcements are meant to serve.

The Government’s push to secure up to $100 million from Afreximbank for roughly 200 miles of Family Island roads dates back to 2025. In its February 11 disclosure, the bank outlined a receivables-discounting facility — a structure that allows a contractor to be paid early once work is completed, certified and invoiced, with the Government settling the bill later. It is not cash placed into the economy upfront. It does not, by itself, build a single mile of road. Every dollar depends on work first being delivered and approved.

The wider framework has been described as support for “climate-resilient and trade-enhancing infrastructure,” a phrase that, in practical terms, should mean projects that lower the cost of doing business, move people and goods faster, and keep the economy functioning. But for communities, that promise becomes real only when the projects are named, the standards are defined and a clear timeline is given for when work will begin — and when it will be finished.

Bahamians have seen this moment before.

In 2023, a $30 million Afreximbank facility for the Bahamas Development Bank was hailed as a breakthrough that would expand access to financing for local enterprise. It worked in one immediate and measurable way: it encouraged businesses to apply. Established, revenue-generating Bahamian companies responded to the call, prepared plans, and entered a process they believed had been capitalised to support growth. The unanswered question is how much of that capital has reached the private sector in a form that allowed those businesses to expand, hire and generate new economic activity.

Because development is not measured in the size of announcements.

It is measured in loans disbursed, projects completed and businesses expanded.

The pattern is becoming difficult to ignore. In June 2024, when Afreximbank held its inaugural Caribbean Annual Meetings in Nassau, Grand Bahama was presented as the future home of an Afro-Caribbean marketplace said to carry tens of millions of dollars in investment. What was confirmed at that stage was a $1.86 million project-preparation facility — funding for studies and planning to make the development bankable, not construction financing. The larger build-out remains dependent on additional approvals, land acquisition and further capital.

This distinction — between financing announced and financing that produces visible, measurable outcomes — is now at the centre of the national conversation.

Because while the numbers grow larger on paper, entrepreneurs still describe access to capital as out of reach, and communities across the Family Islands are still waiting to see where the work will start.

And in an economy where stalled growth translates into lost opportunity, rising frustration and real social consequences, the gap between promise and delivery is no longer a communications issue.

It is an inability to convert announcements into outcomes.

Angle by Deandrea Hamilton. Built with ChatGPT (AI). Magnetic Media — CAPTURING LIFE.  

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