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Cleveland Clinic Performs First-In-World Full Multi-Organ Transplant to Treat Rare Appendix Cancer

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#USA, August 13, 2022 – Cleveland Clinic has successfully performed a first-in-the-world full multi-organ transplant to treat a patient with a rare form of appendix cancer called pseudomyxoma peritonei (PMP). Upon completion of the lifesaving transplant surgery, the patient received five digestive organs: liver, stomach, pancreas, duodenum, and small intestine.

Anil Vaidya, M.D., Cleveland Clinic’s Intestinal Transplant Program co-director, led the seven-surgeon team that completed the pioneering operation on a 32-year-old man in September 2021.

“The patient had one of the more advanced cases of PMP I have seen,” said Dr. Vaidya. “While about 80% of patients with the condition can be treated with traditional therapies, what do you do with the 20% for whom the traditional therapy isn’t successful? In some cases, the answer may be a multi-organ transplant.”

During the 17-hour operation, surgeons removed the patient’s diseased organs. He then received the following deceased donor’s organs all together and at the same time: liver, stomach, pancreas and duodenum (pancreaticoduodenal complex), spleen, small intestine, and right colon. The donor spleen was initially transplanted to boost the immune protection of the newly transplanted organs and improve blood flow to the pancreas until fully transplanted. The donor right colon was initially transplanted to help protect the new intestine from infection and improve its ability to absorb nutrients.  Both the donor spleen and donor right colon were removed prior to the completion of the transplant after they successfully served to protect the other organs during the operation.

“As far as we know, it is the first time in the world that a full multi-organ transplant, including the liver and four other digestive organs, is performed to treat PMP,” said Dr. Vaidya.

Prior to joining Cleveland Clinic in 2020, Dr. Vaidya performed in England the world’s first modified multi-organ transplant (excluding the liver) to treat a patient with PMP who had exhausted all other management strategies.

PMP is a rare cancer that typically originates as a tumor in the appendix. When the slow-growing tumor ruptures, its jelly-like content spreads to other digestive organs, with additional tumors developing that impair gastrointestinal function. Malnutrition and life-threatening complications ultimately occur.

Following the diagnosis in 2019, the patient began a long odyssey of treatments. He was one of the 20% of patients with PMP for whom the traditional treatments were ineffective. Often, this population of patients is left with few to no treatment options.

The patient was referred to Cleveland Clinic in 2021 in the end stage of his disease. He was receiving hospice care at that time. The patient had stopped working and could no longer eat solid foods. He was receiving nutrients intravenously through total parenteral nutrition (TPN).

“We needed to perform an evaluation to determine if transplantation in his case was safe, feasible and could provide long-term benefits,” said Dr. Vaidya.

Dr. Vaidya completed a thorough assessment of the patient’s case and received approval from Cleveland Clinic’s Intestinal Transplant Selection Committee to proceed. The patient was placed on the national transplant waiting list in July 2021.

“The patient – who needed a liver and four other digestive organs – had started to deteriorate quite rapidly,” said Dr. Vaidya. “It was touch-and-go that he would make it.”

In September 2021, a donor was found, and less than 24 hours later, the patient was undergoing the groundbreaking

surgery. The first three hours were preparatory, in essence removing the diseased abdominal organs. Next, the donor organs were inserted into the abdominal cavity, all the necessary vascular connections were completed and a left-sided ileostomy was created to handle bodily waste and let the body recover from the surgery.

“The operation was well planned and went like clockwork,” said Dr. Vaidya. “The team members knew exactly what they were going to do, and the timing was perfect. It went really well.”

Following the transplant, the patient remained in the hospital for 51 days.  Soon after he was discharged, he returned because he was suffering from a case of graft-versus-host disease, a common occurrence following intestinal or bone marrow transplants where the donated organs’ immune cells recognize the recipient’s tissues as foreign and attack the recipient.

The patient underwent a procedure perfected and performed by Amy Lightner, M.D., colorectal surgeon and director of Cleveland Clinic’s Center for Regenerative Medicine and Surgery. Dr. Lightner administered three doses of mesenchymal stromal cell (MSC)-derived exosomes, a first ever, novel treatment in solid organ transplants — another first for a patient who received a full multi-organ transplant to treat PMP.

According to Dr. Vaidya, “The patient’s recovery was absolutely amazing. His symptoms abated within two hours of the first dose.”

Nine months post-transplant, the patient, now 33, can eat and digest solid foods again and has energy to do what he loves, including walking and biking outdoors.

“There is currently no evidence of cancer recurrence,” said Dr. Vaidya.

 

Photo Captions: 

Header: Masato Fujiki, MD, (center) and the Cleveland Clinic surgical team, led by Anil Vaidya, MD, performing the first-in-world multi-organ transplant to treat a rare type of appendix cancer. (Photo courtesy of Cleveland Clinic)

1st insert: Anil Vaidya, M.D.

2nd insert: From left: Anil Vaidya, M.D., Shannon Jarancik, physician assistant, Amy Lightner, M.D., Andy Voge, patient, Rachel Voge, Andy’s wife, and Anita Barnoski, transplant coordinator.

Release: Cleveland Clinic / DPA media

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Cleveland Clinic First in Ohio to Perform Robotic Nipple-Sparing Mastectomy  

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Health system is among only a handful in the U.S. to offer the minimally invasive robotic procedure Cleveland Clinic is among the first hospitals in the country – and the first in Ohio – to perform a robotic nipple-sparing mastectomy procedure, following recent clearance by the U.S. Food and Drug Administration.

Stephanie Valente, D.O., and a surgical team recently performed the first robotic nipple-sparing mastectomy with immediate breast cancer reconstruction at Cleveland Clinic Fairview Hospital. The procedure offers a new minimally invasive approach to breast cancer surgery and risk-reducing mastectomy for patients at elevated risk.

This milestone places Cleveland Clinic among a select group of centers nationwide offering the advanced technology and brings one of the newest innovations in breast cancer surgery to patients in Northeast Ohio.

“This robotic approach offers greater precision through a much smaller incision, which can mean less visible scarring and faster recovery,” said Dr. Valente, director of the Cleveland Clinic Breast Surgery Fellowship Program and director of the West Region Multidisciplinary Breast Program. “Compared with the traditional procedure, which requires a larger incision, this approach can improve cosmetic outcomes, preserve the skin and nipple, and support a more natural appearance after surgery.”

During the procedure, surgeons use a 3D camera and robotic instruments inserted through a small incision of one inch, typically hidden along the side of the breast rather than across the underside, to remove breast tissue while preserving the nipple, areola and skin. The robotic platform, the da Vinci SP Surgical System, provides enhanced visualization and precision while minimizing disruption to the overlying skin.

Robotic surgery gives the surgeon better visualization of the operative field in what is typically a technically challenging procedure. This enhanced view can improve nerve identification and preservation, reduce blood loss and allow surgeons to perform the same oncologic operation through a one-inch incision rather than the traditional five-inch open incision.

The robotic approach removes the same breast tissue as a conventional mastectomy, while changing how the surgeon accesses the breast. For some patients, breast reconstruction can be performed during the same operation.

This approach is designed to reduce scarring, enhance cosmetic outcomes, preserve the natural skin envelope and nipple, improve sensation and accelerate recovery. For some patients, the less visible incision may also support confidence and body image after surgery. The procedure further expands Cleveland Clinic’s minimally invasive breast surgery options, which include endoscopic nipple-sparing mastectomy.

“As a field, we haven’t had many new options for patients with breast surgery for a decade now, so we are pleased to now have these minimally invasive procedures available for our patients,” said Dr. Valente. “Innovations like this support a more patient-centered experience as they allow us to address both the physical and emotional realities of breast cancer.”

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Bahamas News

Walk for the Cure Every Saturday This October  

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Nassau, Bahamas, 1 October 2026 – Every Saturday this month, communities across The Bahamas will take steps in support of cancer patients and survivors as CIBC Caribbean’s Walk for the Cure returns to New Providence, Abaco, Eleuthera, and Grand Bahama.

CIBC Caribbean Head of Country, Terrance Gibson, said, “Each Saturday in October represents another community coming together, another opportunity to raise awareness and, most importantly, more support for the organizations that are doing this work every day.”

The month of activities begins this Saturday, October 3, in New Providence, with participants gathering at the Goodman’s Bay Corporate Centre for a 6:30am start.

CIBC Caribbean Walk Champion, Antionette Fox, said the series of walks gives communities across the country an opportunity to contribute to a cause that directly supports Bahamian cancer organizations.

“Every Saturday for the month of October, there will be a walk that you can participate in to contribute towards this worthy cause,” Fox said.

In New Providence, the morning will extend beyond the walk itself, with Zumba, wellness activities, informational vendors, and opportunities for participants to connect with organizations working directly with cancer patients and survivors.

Gennie Dean Caring and Sharing Cancer Support Group President Duquesa Dean said participants do not have to complete the full route to be part of the morning.

“Just come out…there is something for everyone, come for the community,” Dean said. “There’s a survivor ceremony, so come and participate and celebrate the people who have gone through cancer and are here as evidence that you could live after a cancer diagnosis.”

The Gennie Dean Caring and Sharing Cancer Support Group is one of eight cancer organizations in The Bahamas that benefit from funds raised through Walk for the Cure. The others are the Sister Sister Breast Cancer Support Groups of New Providence and Grand Bahama, Cancer Society of The Bahamas, the Cancer Societies of Abaco, Eleuthera, and Grand Bahama, and the Cancer Association of Grand Bahama.

Dean explained that CIBC Caribbean covers the cost of staging WFTC, allowing donations raised to support the work of beneficiary organizations.

For her organization, that assistance translates into tangible support for people navigating cancer, including food assistance, financial aid, prosthetic breasts, and mastectomy bras, as well as programs such as Step Into Wellness, which promotes movement and healthy living among cancer patients and survivors.

Corporate partners are also helping to strengthen this year’s effort. Bamboo Shack has joined the initiative as a gold sponsor, with representative Ghandi Pinder sharing that the cause has a personal significance for her.

Pinder recalled shaving her hair in solidarity with her sister after she was diagnosed with an aggressive form of breast cancer and began losing her hair during chemotherapy.

“We see you, we’re here with you, we’re in it with you,” Pinder said of Bamboo Shack’s message to those affected by cancer.

She also encouraged more of Corporate Bahamas to support initiatives that directly impact the communities they serve.

“At Bamboo Shack, we always say a better Bahamas begins with you… Together, we can make a difference,” she said.

Registration for Walk for the Cure is $30 for adults and $15 for children and can be completed at any CIBC Caribbean branch. CIBC Caribbean clients can also donate through online banking.

The New Providence Walk begins promptly at 6:30am on Saturday, October 3, at the Goodman’s Bay Corporate Centre, followed by Walk for the Cure events in other islands each Saturday throughout October. The Grand Bahama WFTC event will be held on October 10 and the Abaco and Eleuthera WFTC events will occur on October 17 and October 24 respectively.

Gibson added, “Some will walk for themselves, some in celebration of a survivor, and others in memory of someone they have lost. Whatever brings you to Walk for the Cure, every person who shows up becomes part of a much bigger expression of support for those affected by cancer.”

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TCI Hospital Marks Breast Cancer Awareness Month 2026 with “Know. Check. Act. Support.” Campaign

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Ten-Year Cancer Register Profile reinforces the importance of breast awareness, appropriate screening, timely diagnosis and continuing cancer care

 

Providenciales, Turks and Caicos Islands – 1st October 2026 – Turks and Caicos Islands Hospital (TCI Hospital) is marking Breast Cancer Awareness Month 2026 with a month-long public awareness campaign under the theme “Know. Check. Act. Support. – Early Detection Saves Lives.”

This year’s campaign is being informed by TCI Hospital’s Ten-Year Cancer Register Profile, 2016–2025, which demonstrates that breast cancer remains an important and continuing healthcare issue for patients, families and the wider Turks and Caicos Islands community.

Throughout the ten-year period, TCI Hospital continued to record new cases of malignant neoplasms of the breast each year. Annual new registrations fluctuated, reinforcing an important message: breast cancer is not an occasional concern confined to Breast Cancer Awareness Month, it requires sustained awareness, appropriate screening, timely investigation and diagnosis, access to treatment, follow-up and support throughout the year.

What Our Cancer Register Tells Us

The TCI Hospital Cancer Register recorded 21 new breast cancer cases in 2016, the highest annual figure reported during the ten-year profile. In subsequent years, the overall annual new-case count ranged from 8 to 18 cases, with 18 new cases recorded in 2024 and 10 in 2025.

The register also demonstrates the continuing accumulation of breast cancer cases within the hospital’s cancer records. The total registered breast cancer caseload increased from 79 in 2016 to 192 by 2025. More recently, the register increased from 160 cases in 2023 to 181 in 2024 and 192 in 2025. These figures represent the hospital’s registered caseload and should not be interpreted as population incidence, prevalence or the number of people currently living with breast cancer.

Behind every registration is more than a statistic. Each represents a person whose diagnosis has implications for their family and for the healthcare professionals and services involved in cancer investigation, treatment, coordination, follow-up and support.

The ten-year profile therefore reinforces the importance not only of identifying breast cancer, but of ensuring that people affected by the disease are supported throughout their cancer journey.

Know the Signs and Act on Changes

Breast cancer can present in different ways. Changes that should prompt assessment by a healthcare professional may include a new lump or thickening in the breast or underarm; a change in the size, shape or appearance of a breast; dimpling, puckering or other unusual changes to the breast skin; nipple changes or unusual discharge; or another new or persistent breast change.

Finding a change does not necessarily mean that a person has cancer. However, an unexplained or persistent change should not be ignored.

TCI Hospital encourages members of the community to become familiar with what is normal for their breasts and to seek medical advice if they notice something different.

Know Your Risk. Know Your Family History.

Breast cancer risk is influenced by several factors. Understanding personal and family medical history can help individuals have more informed conversations with their healthcare providers about their individual risk.

Having no known family history of breast cancer does not mean that breast health can be ignored. Equally, people with a significant family history or other factors that may increase their risk should discuss this with an appropriate healthcare professional.

The TCI Hospital Cancer Register also records male breast cancer, reminding the community that although breast cancer predominantly affects women, it can also occur in men.

Screening and Early Diagnosis Matter

Breast awareness and screening have different but complementary purposes. Screening is intended to identify possible breast abnormalities in people who may not have symptoms, while a new or concerning breast change requires appropriate clinical assessment.

There is no single screening approach that is appropriate for every individual. TCI Hospital therefore encourages people to discuss their age, personal risk factors, family history and appropriate breast screening with their healthcare provider.

Similarly, people experiencing a concerning breast change should not wait for their next routine screening appointment before seeking medical advice.

The campaign’s message “Early Detection Saves Lives” emphasizes the importance of timely action. It does not mean that every breast change is cancer. Rather, seeking medical attention allows appropriate investigation to take place and, where cancer is diagnosed, enables the healthcare team to determine the most appropriate next steps.

From Cancer Registration to Better Cancer Care

TCI Hospital Chief Executive Officer Dr Denise Braithwaite-Tennant said the Cancer Register has an important role beyond recording the number of cancer cases seen by the hospital.

“Our Cancer Register is not simply about counting cases. It helps us understand the cancer burden presenting to our hospital, identify patterns over time and inform how we plan and strengthen cancer services. Behind every number is a patient, a family and a cancer journey. The continued recording of new breast cancer cases reminds us why awareness must lead to action and why our health system must continue to strengthen the pathway from appropriate screening and timely diagnosis through treatment, follow-up and survivorship support.”

“During Breast Cancer Awareness Month, we want our community to understand that fear should not become a reason to delay seeking care. Know what is normal for you, understand your risk, participate in screening that is appropriate for you and seek medical advice when something changes. Just as importantly, we must continue to support those undergoing cancer treatment and those living beyond a cancer diagnosis.”

Know. Check. Act. Support.

Throughout October, TCI Hospital will deliver a programme of activities designed to turn breast cancer awareness into practical action.

Activities will include an educational breast cancer awareness video addressing signs and symptoms, screening, early detection and support; publication of findings from the TCI Hospital Ten-Year Cancer Register Profile, 2016–2025; breast cancer facts and educational messages; a special House Call – Pink Round Table addressing breast cancer risk, symptoms, diagnosis, treatment and survivorship; and Pink Fridays, during which TCI Hospital team members will wear pink to promote awareness, early detection, survivorship and support.

The campaign will also highlight the important role of families, friends, caregivers, healthcare professionals and the wider community. Support can take many forms; from listening and accompanying someone to an appointment to assisting with transportation, meals, childcare or other practical needs during treatment.

TCI Hospital’s Breast Cancer Awareness Month message to the Turks and Caicos Islands community is:

KNOW – Know your body, your family history and your individual risk.

CHECK – Participate in appropriate screening and pay attention to changes.

ACT – Do not ignore a new or concerning breast change. Seek medical advice.

SUPPORT – Stand with patients, survivors, families and others affected by breast cancer.

Know. Check. Act. Support.

Early Detection Saves Lives.

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