Health
Cleveland Clinic: First Patient to Receive Breast Cancer Vaccine Shares Health Journey
The vaccine targets a lactation protein called α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in most triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing. (Courtesy: Cleveland Clinic)
#USA, April 17, 2023 – During a typical day at work, Jennifer Davis received an unexpected call that changed her life. A nurse on the other end of the line delivered the news Jennifer had triple-negative breast cancer. The mother of three recalls feeling terrified. She didn’t know how she was going to tell her family. After receiving the diagnosis, Jennifer knew she wanted to take advantage of every treatment option available. Through her driven search for answers, she became the first person to participate in a novel study at Cleveland Clinic for a vaccine that aims to eventually prevent triple-negative breast cancer.
“When I found out I was the first person to receive the vaccine, I was excited. I was thrilled. The trial has given me a lot of hope,” says Jennifer, a registered nurse from Lisbon, Ohio.
Jennifer’s health journey started in February 2018 when she felt a lump in her breast. She went to a local hospital for follow-up, and her first biopsy showed no evidence of cancer. Months went by, and Jennifer says the lump grew. She listened to her body and continued to get it checked. Jennifer eventually received another biopsy after doctors detected abnormalities during an ultrasound. Her diagnosis was confirmed about one week later, and she sought a second opinion for her treatment.
“I knew I wanted to go to Cleveland Clinic, so I had my first appointment there shortly after. I met my entire care team within my first few appointments and had a complete treatment plan. I was very happy with my team and was anxious to get started,” says Jennifer.
As part of the plan, she underwent multiple rounds of chemotherapy and radiation. She also had a double mastectomy performed by breast surgeon Zahraa AlHilli, MD.
“After the double mastectomy, I was adamant while in recovery about wanting to know what they found and whether the cancer had spread. Dr. AlHilli was able to get clear margins, and there were no signs the cancer had spread anywhere else,” says Jennifer.
After undergoing treatment, it was during her follow-up appointments with breast medical oncologist Megan Kruse, MD, she learned about the breast cancer vaccine clinical trial.
The vaccine is based on pre-clinical research led by the late Vincent Tuohy, PhD, who was the Mort and Iris November Distinguished Chair in Innovative Breast Cancer Research at Cleveland Clinic’s Lerner Research Institute. The vaccine targets a lactation protein called α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in most triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing.
Research nurse coordinator Donna Lach administers the third dose of the breast cancer vaccine to Jennifer. (Courtesy: Cleveland Clinic)
“Triple-negative breast cancer is the form of the disease for which we have the least effective treatments,” said G. Thomas Budd, MD, breast medical oncologist and principal investigator for the breast cancer vaccine trial. “Long term, we are hoping this can be a true preventive vaccine that would be administered to cancer-free individuals to prevent them from developing this highly aggressive disease.”
Jennifer is involved in phase 1a of the study, which includes patients who completed treatment for early-stage, triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence.
“There is no medication I take to make sure there’s not a recurrence,” says Jennifer. “With every ache and pain, your mind goes to the worst-case scenario. So, I was very excited when I heard about the vaccine.”
In October 2021, Jennifer became the first patient to enroll in the trial and receive the first dose of the vaccine. “I didn’t think twice about getting the vaccine and haven’t looked back since.”
Dr. Kruse says, “For a long time with triple-negative breast cancer, the overarching theme patients talked about is how they’re going through all this treatment but still feeling like they’re destined to have the cancer return. I think having the hope of this vaccine study where we can potentially turn that around and have some optimism as we approach the future for these patients is the best part.”
Over the course of the study, Jennifer and other participants received three doses of the vaccine. The vaccinations were each given two weeks apart, and the participants were closely monitored for side effects and immune response. She received her last dose in November 2021 and has not noted any major side effects.
“My husband went with me for the first vaccine. Then my mom went with me for the second and third,” says Jennifer. “I don’t know if I ever went to an appointment at Cleveland Clinic by myself, and that support has meant a lot to me.”
Jennifer is hopeful about the vaccine trial and encourages others to stay positive amid the ongoing research. (Courtesy: Cleveland Clinic)
In February 2023, Cleveland Clinic researchers launched the next step in their study of the vaccine. The phase 1b clinical trial, conducted in partnership with Anixa Biosciences, Inc., focuses on individuals who are cancer-free, at high risk for developing breast cancer and have decided to voluntarily undergo a prophylactic mastectomy to lower their risk.
Meanwhile, Jennifer, now 46 years old, continues to follow up with Dr. Kruse as she nears her fifth year of being in remission. Although it will take years to fully understand the vaccine’s effectiveness, she’s eager for what’s to come and hopes her story can help others diagnosed with breast cancer.
“Even though you’re going to have days where you’re not positive, where you feel terrible – keep moving forward. If the vaccine works the way they want, it could prevent triple-negative breast cancer one day,” says Jennifer.
Editor’s note: Dr. Tuohy was inventor of the technology, which Cleveland Clinic exclusively licensed to Anixa Biosciences. He was entitled to a portion of the commercialization revenues received by Cleveland Clinic and also held equity in the company.
Related Institutes: Lerner Research Institute, Cleveland Clinic Cancer Center
(Providenciales – Monday, March 2, 2026) TCI Hospital proudly announces the successful achievement of its Heart Strong TCI initiative, a comprehensive Heart Month campaign focused on raising awareness and strengthening cardiovascular disease prevention efforts across the Turks and Caicos Islands.
Heart disease remains the leading cause of death in the Turks and Caicos Islands, highlighting the critical need for sustained public education, risk-factor reduction, and early intervention. The Heart Strong TCI initiative was designed to actively engage the community through education, outreach, and physical activity.
Key Activities Included:
Educational Training Sessions
Healthcare professionals conducted structured sessions addressing hypertension, diabetes, cholesterol management, nutrition, exercise, smoking cessation, and the early warning signs of heart disease.
House Call Talk Show Feature
A dedicated Heart Month episode of the hospital’s House Call program provided expert discussion on cardiovascular risk factors and prevention strategies, empowering viewers with practical, evidence-based guidance.
Red Fridays Awareness Campaign
Throughout the month, staff wore red every Friday to increase visibility around heart disease awareness and reinforce the campaign’s message within the community.
Heart Strong 5K Walk/Run
In collaboration with the Rotary Club, TCI Hospital hosted a community-wide 5K walk/run to promote physical activity as a cornerstone of
heart health. The walk/run also provided an opportunity for community screening.
Digital Health Education Campaign
To expand its reach, TCI Hospital also shared ongoing heart health education tips and prevention messages across its social media platforms, including Facebook, LinkedIn, and Instagram. These posts provided actionable guidance on diet, exercise, blood pressure control, and lifestyle modification, and encouraging community members to learn CPR.
Heart Strong TCI: A Continuous Commitment
While Heart Month has officially ended, Heart Strong TCI represents an ongoing institutional commitment to cardiovascular disease prevention and awareness. TCI Hospital will continue to prioritize:
- Community-based education initiatives
- Preventative screening and early detection programs
- Lifestyle and wellness promotion
- Strategic partnerships that advance public health outcomes
“Heart Strong TCI is not limited to a single month,” CEO, Dr. Denise Braithwaite-Tennant. “Cardiovascular disease prevention requires sustained effort. We remain committed to promoting healthy hearts across the Turks and Caicos Islands year-round.”
For more information about cardiovascular health services or upcoming screening initiatives, please contact TCI Hospital at 649-941-2800 in Providenciales, 649-941-2900 in Grand Turk or email us at info@interhealthcanada.tc
About TCI Hospital
TCI Hospital is dedicated to delivering high-quality healthcare services to the people of the Turks and Caicos Islands, with a strong emphasis on prevention, education, and community wellness.
February is National Self- Check Month and family medicine physician at Cleveland Clinic, OH, John Hanicak, MD, highlights why at home self-checks are extremely important when it comes to not just early cancer detection but identifying other illnesses too and offers tips on what to look out for.
“Sometimes I look at them as sort of like your check engine light on the car, just like there would be a red flashing light that tells you that
there’s something wrong with a car and prompts you to bring that in and get serviced. Your body does the same thing. It gives you warning signs to look into that symptom a little bit further,” said Hanicak.
Dr. Hanicak said self-checks are going to be a little different for everyone.
However, in general, he recommends looking for anything that may seem abnormal, such as unexplained weight loss, blood in your urine, bumps and bruises that won’t heal, and changes in bowel habits.
For example, if you suddenly start going to the bathroom a lot more than you used to, that could be a sign of something more serious.
He also suggests doing regular skin checks and documenting any moles or spots that start to look different.
“Realize that you are your own person. There’s nobody else in the world exactly like you. You’ve got your own set of ideas, your own family history and your own genetics. Know what is normal for you, and when that changes, that’s the kind of thing that we would be interested in talking about,” said Dr. Hanicak.
Dr. Hanicak notes that self-checks are not meant to replace cancer screenings, as those are just as important to keep up with.
Press Release: Cleveland Clinic
December 4, 2025 – Hollywood legend Bruce Willis – arguably the most famous former home owner in Turks and Caicos Islands – is facing the most difficult role of his life and turning it into one last act of service.
Willis, 70, retired from acting in 2022 after his family revealed he had been diagnosed with aphasia. The following year, specialists
confirmed he is living with frontotemporal dementia (FTD), a degenerative brain disease that attacks language, behaviour and personality.
In recent interviews and appearances, his wife Emma Heming Willis has said Bruce is “surrounded by love and care” and that the family is learning to find joy in new ways, even as the disease progresses.
Now, Heming Willis has gone further. In her 2025 memoir The Unexpected Journey, she writes that the family has decided Bruce’s brain will be donated to science after his death to advance research into FTD. That decision has been highlighted in recent coverage by futurist and science outlets, which describe it as a carefully considered step after months of watching a still-physically-strong man steadily lose speech, reading and independence.
Neurologists have long stressed how rare donated brain tissue is for FTD, and how essential it is to understanding which proteins, mutations and mechanisms are actually driving the disease. The Willis family’s choice means the brain that powered some of cinema’s most iconic characters could one day help researchers diagnose the condition earlier and design better treatments – even if it cannot help Bruce himself.
For Turks and Caicos, the story lands close to home. For nearly two decades Willis owned “The Residence” on exclusive Parrot Cay – a 7.3-acre, Asian-inspired beachfront compound with a five-bedroom main house, two guest villas and a yoga pavilion. He and Emma listed the estate in March 2019 for US$33 million; it sold a few months later for about US$27 million, one of the biggest residential deals in TCI history.
So, while Bruce Willis no longer has a physical address in Turks and Caicos, his connection to these islands remains part of his global story – a story now shifting from blockbuster fame to medical legacy, as his family turns private heartbreak into a public contribution that could change what we know about dementia.
Developed by Deandrea Hamilton • with ChatGPT (AI) • edited by Magnetic Media.
