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Cleveland Clinic: First Patient to Receive Breast Cancer Vaccine Shares Health Journey

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The vaccine targets a lactation protein called α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in most triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing. (Courtesy: Cleveland Clinic)

#USA, April 17, 2023 – During a typical day at work, Jennifer Davis received an unexpected call that changed her life. A nurse on the other end of the line delivered the news Jennifer had triple-negative breast cancer. The mother of three recalls feeling terrified. She didn’t know how she was going to tell her family. After receiving the diagnosis, Jennifer knew she wanted to take advantage of every treatment option available. Through her driven search for answers, she became the first person to participate in a novel study at Cleveland Clinic for a vaccine that aims to eventually prevent triple-negative breast cancer.

“When I found out I was the first person to receive the vaccine, I was excited. I was thrilled. The trial has given me a lot of hope,” says Jennifer, a registered nurse from Lisbon, Ohio.  

Jennifer’s health journey started in February 2018 when she felt a lump in her breast. She went to a local hospital for follow-up, and her first biopsy showed no evidence of cancer. Months went by, and Jennifer says the lump grew. She listened to her body and continued to get it checked. Jennifer eventually received another biopsy after doctors detected abnormalities during an ultrasound. Her diagnosis was confirmed about one week later, and she sought a second opinion for her treatment.  

“I knew I wanted to go to Cleveland Clinic, so I had my first appointment there shortly after. I met my entire care team within my first few appointments and had a complete treatment plan. I was very happy with my team and was anxious to get started,” says Jennifer.  

As part of the plan, she underwent multiple rounds of chemotherapy and radiation. She also had a double mastectomy performed by breast surgeon Zahraa AlHilli, MD.  

“After the double mastectomy, I was adamant while in recovery about wanting to know what they found and whether the cancer had spread. Dr. AlHilli was able to get clear margins, and there were no signs the cancer had spread anywhere else,” says Jennifer.  

After undergoing treatment, it was during her follow-up appointments with breast medical oncologist Megan Kruse, MD, she learned about the breast cancer vaccine clinical trial.  

The vaccine is based on pre-clinical research led by the late Vincent Tuohy, PhD, who was the Mort and Iris November Distinguished Chair in Innovative Breast Cancer Research at Cleveland Clinic’s Lerner Research Institute. The vaccine targets a lactation protein called α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in most triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing.  

Research nurse coordinator Donna Lach administers the third dose of the breast cancer vaccine to Jennifer. (Courtesy: Cleveland Clinic)

“Triple-negative breast cancer is the form of the disease for which we have the least effective treatments,” said G. Thomas Budd, MD, breast medical oncologist and principal investigator for the breast cancer vaccine trial. “Long term, we are hoping this can be a true preventive vaccine that would be administered to cancer-free individuals to prevent them from developing this highly aggressive disease.”  

Jennifer is involved in phase 1a of the study, which includes patients who completed treatment for early-stage, triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence.  

“There is no medication I take to make sure there’s not a recurrence,” says Jennifer. “With every ache and pain, your mind goes to the worst-case scenario. So, I was very excited when I heard about the vaccine.”  

In October 2021, Jennifer became the first patient to enroll in the trial and receive the first dose of the vaccine. “I didn’t think twice about getting the vaccine and haven’t looked back since.”  

Dr. Kruse says, “For a long time with triple-negative breast cancer, the overarching theme patients talked about is how they’re going through all this treatment but still feeling like they’re destined to have the cancer return. I think having the hope of this vaccine study where we can potentially turn that around and have some optimism as we approach the future for these patients is the best part.”  

Over the course of the study, Jennifer and other participants received three doses of the vaccine. The vaccinations were each given two weeks apart, and the participants were closely monitored for side effects and immune response. She received her last dose in November 2021 and has not noted any major side effects.  

“My husband went with me for the first vaccine. Then my mom went with me for the second and third,” says Jennifer. “I don’t know if I ever went to an appointment at Cleveland Clinic by myself, and that support has meant a lot to me.”  

Jennifer is hopeful about the vaccine trial and encourages others to stay positive amid the ongoing research. (Courtesy: Cleveland Clinic)

In February 2023, Cleveland Clinic researchers launched the next step in their study of the vaccine. The phase 1b clinical trial, conducted in partnership with Anixa Biosciences, Inc., focuses on individuals who are cancer-free, at high risk for developing breast cancer and have decided to voluntarily undergo a prophylactic mastectomy to lower their risk.  

Meanwhile, Jennifer, now 46 years old, continues to follow up with Dr. Kruse as she nears her fifth year of being in remission. Although it will take years to fully understand the vaccine’s effectiveness, she’s eager for what’s to come and hopes her story can help others diagnosed with breast cancer.  

“Even though you’re going to have days where you’re not positive, where you feel terrible – keep moving forward. If the vaccine works the way they want, it could prevent triple-negative breast cancer one day,” says Jennifer.  

Editor’s note: Dr. Tuohy was inventor of the technology, which Cleveland Clinic exclusively licensed to Anixa Biosciences. He was entitled to a portion of the commercialization revenues received by Cleveland Clinic and also held equity in the company.

Related Institutes: Lerner Research InstituteCleveland Clinic Cancer Center

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Environmental Health Department Offers Tips for Preventing Rodent Infestations  

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Turks and Caicos, September 14, 2024 – The Environmental Health Department is calling on all residents and community members to take proactive steps to prevent rodent infestations in their homes and neighbourhoods. Rodents, such as rats and mice, are not only a nuisance but can also spread serious diseases and cause property damage. By following a few simple guidelines, we can work together to keep our community healthy and safe.

Here are some key steps residents can take to prevent rodent problems:

  1. Keep Areas Clean and Clutter-Free:Rodents thrive in cluttered environments. Regularly remove piles of trash, leaves, and debris from your yard. Pay attention to overgrown vegetation and make sure to trim it back, as it can provide hiding spots for rodents. Also, clean up fallen fruits from trees, which can attract rodents seeking food.
  2. Store Food Properly:Keep food items in sealed containers and ensure garbage bins have tight-fitting lids. Rodents are attracted to easily accessible food, so reducing food sources is essential.
  3. Eliminate Water Sources:Fix any leaks and remove standing water around your property. Rodents need water to survive, so by eliminating these water sources, you make your home less inviting to them.
  4. Seal Entry Points:Inspect your home for holes or cracks in walls, doors, windows, and foundations. Seal these openings to prevent rodents from finding their way inside. Even small gaps can be entry points, so thorough inspection and repair are necessary.

The Environmental Health Department urges residents to remain vigilant and report any signs of rodent activity. Common indicators include droppings, gnaw marks, and scratching noises. If you suspect a rodent infestation, contact a pest control professional or the Environmental Health Department for assistance.

By taking these simple steps, including maintaining tidy yards, managing food and water sources, and sealing potential entry points, residents can protect their homes and communities from rodent infestations.

For more information on rodent prevention or to report a rodent problem, please contact the Environmental Health Department at (649) 338-2143/2144. Let’s work together to create a healthier, safer community!

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The Ministry of Health and Human Services Warns Public About Heat-Related Illnesses Amid Rising Temperatures

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Turks and Caicos, September 13, 2024 – With the summer heat intensifying, the Ministry of Health and Human Services is urging the public to take precautions against heat-related illnesses, which can pose serious health risks. Heat-related illnesses include conditions such as heat stroke, heat exhaustion, heat cramps, and heat rash. Vulnerable populations, such as young children, the elderly, and those with chronic medical conditions, are at increased risk.

Understanding Heat-Related Illnesses:

  1. Heat Stroke: A life-threatening condition where the body’s temperature rises above 103°F. Symptoms include confusion, hot and dry skin, rapid pulse, and loss of consciousness.
  2. Heat Exhaustion: Symptoms include heavy sweating, weakness, dizziness, nausea, and fainting. It can lead to heat stroke if not addressed promptly.
  3. Heat Cramps: Painful muscle spasms usually occurring in the legs or abdomen, often due to heavy sweating and loss of salt and water.
  4. Heat Rash: Skin irritation caused by excessive sweating, presenting as red clusters of small blisters.

 Prevention Tips

  1. Stay Hydrated: Drink plenty of fluids, especially water. Limit alcohol and caffeine, which can dehydrate you.
  2. Stay Cool: Spend time in air-conditioned environments.
  3. Dress Appropriately: Wear lightweight, light-coloured, and loose-fitting clothing. Use hats and sunscreen when outdoors.
  4. Limit Outdoor Activities: Limit strenuous activities during the hottest parts of the day, typically between 10 a.m. and 4 p.m. Plan outdoor events for the cooler morning or evening hours. Take frequent breaks in the shade or indoors if you must be outside.
  5. Check on Vulnerable Individuals: Ensure that family members, friends, and neighbours, especially those who are elderly or have health conditions, are staying cool and hydrated.

If someone shows signs of heat-related illness:

  1. Move them to a cooler environment
  2. Apply cool, wet cloths to their body or have them take a cool bath.
  3. Offer sips of water if they are conscious.
  4. Call 911 immediately if you suspect heat stroke.

The Minister of Health and Human Services, Honourable Shaun D. Malcolm, commented, “We want to ensure that everyone stays safe during these extreme heat conditions. By taking simple preventive measures, we can reduce the risk of heat-related illnesses. Our goal is to inform and protect the community, especially our most vulnerable members.

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Ministry of Health and Human Services Reports Outbreak of Gastroenteritis in Grand Turk  

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Turks and Caicos, September 12, 2024 – The Ministry of Health and Human Services (MoHHS) reports an outbreak of gastroenteritis affecting the island of Grand Turk. Gastroenteritis (GE), which causes diarrhoea and or vomiting,  can be triggered by viral or bacterial infections resulting in inflammation of the stomach and intestines. These infections can spread easily from person to person by direct contact, contact with contaminated food or water, or contact with contaminated surfaces/objects. Some people (usually the very young or elderly) are very vulnerable and may require hospital admission due to dehydration. It is, therefore, essential to drink plenty of fluids during the illness to avoid dehydration.

The public health team has been actively responding since initial reports and, to date, has done a number of inspections and provided advice. A number of school-aged children from various schools, along with their close contacts have been affected. The Ministry of Education has been apprised of the situation, and the MoHHS is working closely with its education partners to mitigate further spread.

Gastroenteritis can commonly occur in school and nursery settings and may be caused by viruses such as norovirus or, more rarely, by food poisoning. Symptoms commonly include:

  • vomiting (often sudden in onset)
  • diarrhoea
  • both diarrhoea and vomiting
  • tiredness
  • fever
  • nausea (feeling sick)
  • aching muscles
  • stomach pain
  • headache

 Symptoms may begin one to two days after infection and typically resolve in one to three days.

 Recommendations:

  1. Practising proper hand hygiene at all timesis essential to prevent the spread of GE and other communicable diseases.

Children should be supervised and encouraged to wash their hands before eating, drinking, and after using the toilet.

Hand washing with liquid soap and warm water should be done frequently for at least 20 seconds.

Paper towels should be used for drying hands, and a wastepaper bin should be provided for disposal.

Persons looking after ill loved ones should pay particular attention to proper hand hygiene to prevent getting sick.

Alcohol gel can be used in addition to soap and water.

  1. Handle and prepare food safely. Before preparing and eating your food:

Carefully wash fruits and vegetables well.

Clean and sanitise kitchen utensils, cutting boards, counters, and surfaces routinely.

  1. Practice proper cleaning and disinfection, particularly of frequently touched surfaces.

Surfaces and touch points (taps, toilet flush handles, door handles, light switches) should be cleaned and disinfected with a bleach-based cleaner.

Use detergents and bleach solutions in accordance with the manufacturer’s instructions to clean these surfaces regularly.

  1. If you or your child is sick, you should not go to school/work and not return until at least 48 hours after the symptoms have resolved without medication.
  2. Ensure that you or your child is properly hydrated.Avoid dehydration by offering an oral rehydration solution gradually.
  3. Seek medical attentionif your child:
  • Becomes unusually drowsy
  • Vomits frequently or vomits blood
  • Has bloody diarrhoea
  • Shows signs of dehydration, such as dry mouth and skin, marked thirst, sunken eyes, or crying without tears. In an infant, be alert to the soft spot on the top of the head becoming sunken and to diapers that remain dry for more than three hours
  • Is an infant and has a fever
  • Is older than three months of age and has a fever of 102 Fahrenheit (39 degrees Celsius) or more

The Ministry of Health and Human Services will continue heightened surveillance for gastroenteritis and take necessary actions to mitigate against further cases.

For additional information, please call 649-338-5469 or visit the Ministry of Health and Human Services Facebook page at https://www.facebook.com/tciministryofhealth/.

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