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Cleveland Clinic Announces Next Step in Preventive Breast Cancer Vaccine Study

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Clinical trial now studying cancer-free individuals at high risk for developing breast cancer

 

Cleveland Clinic researchers have launched the next step in their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

Funded by the U.S. Department of Defense, the new phase 1b study will enroll cancer-free individuals at high risk for developing breast cancer who have decided to voluntarily undergo prophylactic mastectomy to lower their risk.

Individuals in that category typically carry genetic mutations that put them at risk of developing triple-negative breast cancer or have high familial risk for any breast cancer. The study, conducted at Cleveland Clinic’s main campus, will evaluate safety and monitor immune response.

The new study will include approximately 6-12 patients and is anticipated to be complete by the end of 2023. Study participants will receive three vaccinations given two weeks apart and will be closely monitored for side effects and immune response.

The phase 1b clinical trial, conducted in partnership with Anixa Biosciences, Inc., follows the ongoing phase 1a study, which opened in 2021 and is expected to be complete in the  4th quarter of 2023. The phase 1a trial includes patients who completed treatment for early-stage, triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence.

“Triple-negative breast cancer is the form of the disease for which we have the least effective treatments,” said G. Thomas Budd, M.D., of Cleveland Clinic’s Taussig Cancer Institute and principal investigator of the study. “Long term, we are hoping that this can be a true preventive vaccine that would be administered to cancer-free individuals to prevent them from developing this highly aggressive disease.”

According to Dr. Budd, there is a great need for improved treatments for triple-negative breast cancer, which does not have biological characteristics that typically respond to hormonal or targeted therapies. Despite representing only about 12% to 15% of all breast cancers, triple-negative breast cancer accounts for a disproportionately higher percentage of breast cancer deaths. It is twice as likely to occur in Black women, and approximately 70 to 80% of the breast tumors that occur in women with mutations in the BRCA1 gene are triple-negative breast cancer.

The vaccine is based on pre-clinical research led by the late Vincent Tuohy, Ph.D., who was the Mort and Iris November Distinguished Chair in Innovative Breast Cancer Research at Cleveland Clinic’s Lerner Research Institute. Dr. Tuohy was an outstanding and passionate scientist and his decades of groundbreaking research led to the development of this investigational vaccine.

The vaccine targets a lactation protein, α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in the majority of triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing.

The study is based on Dr. Tuohy’s research that showed that activating the immune system against α-lactalbumin was safe and effective in preventing breast tumors in mice. The research, originally published in Nature Medicine, was funded in part by philanthropic gifts from more than 20,000 people over the last 12 years.

“It was Dr. Tuohy’s hope that this vaccine would demonstrate the potential of immunization as a new way to control breast cancer, and that a similar approach could someday be applied to other types of malignancy,” added Dr. Budd.

For more information and eligibility requirements visit clinicaltrials.gov.

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Caribbean News

CARICOM Presses for Peace as Hormuz Conflict Drives Up Caribbean Costs 

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May 22, 2026 – The Caribbean Community is warning that the escalating conflict surrounding the Strait of Hormuz is now directly threatening Caribbean economies, driving up the cost of fuel, food and freight across a region heavily dependent on imports.

In a statement issued this week, CARICOM expressed “serious concern” over the worsening hostilities in the Middle East and the growing instability affecting one of the world’s most critical shipping corridors.

CARICOM said it is alarmed by: “the severe loss of life, threats to civil infrastructure, and the instability in global markets” resulting from the conflict.

The regional bloc warned that disruption in maritime transit through the Strait of Hormuz is reverberating across the global economy through: “energy markets, supply chains and increased freight costs.”

For Caribbean citizens, those consequences are already becoming painfully visible.

In Nassau, gasoline prices have surged again, with regular fuel now nearing or exceeding seven dollars per gallon at some stations. Consumers in other CARICOM countries are also reporting higher transportation costs, rising grocery bills and mounting pressure on household budgets.

The fear among regional leaders is that the crisis is far from over.

Roughly 20 percent of the world’s oil and liquefied natural gas normally passes through the Strait of Hormuz, making it one of the most strategically important waterways in global trade. Analysts warn prolonged disruption could trigger even higher global inflation and deeper supply chain instability.

The United Nations Food and Agriculture Organization has now warned that the crisis could become a: “systemic agrifood shock” capable of triggering a severe global food price crisis within six to twelve months.

The Caribbean is especially vulnerable because of its dependence on imported fuel, imported food and imported manufactured goods.

A recent UN regional analysis warned that shockwaves from the Middle East conflict are already reaching Caribbean nations, where rising oil prices and freight costs are increasing the price of imported food, electricity and transportation.

Global institutions are also sounding increasingly dire warnings.

The World Bank projects energy prices could surge by 24 percent this year because of the conflict, while fertilizer prices may jump by more than 30 percent — increases likely to feed directly into higher food costs worldwide.

The International Monetary Fund has meanwhile warned the global economy could face a “much worse outcome” if the conflict drags into 2027 and oil prices continue climbing.

CARICOM is now calling for all parties to respect international law and preserve safe passage through the Strait of Hormuz under the United Nations Convention on the Law of the Sea.

The Community stressed that transit passage:  “should not be contingent on any license, levy, or authorization,” and warned that bordering states should not “hamper or suspend” the movement of vessels through the corridor.

CARICOM also called for:  “cessation of hostilities” and urged “de-escalation and restraint by all parties.”

But for many Caribbean citizens, the economic pain is already here.

And with fuel nearing seven dollars per gallon in parts of The Bahamas, regional governments are facing renewed pressure over cost of living concerns, inflation and the Caribbean’s continued dependence on imported energy and food supplies.

Angle by Deandrea Hamilton. Built with ChatGPT (AI). Magnetic Media — CAPTURING LIFE.

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Caribbean News

Browne Wins Fourth Term in Antigua & Barbuda Landslide

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Antigua & Barbuda, May 4, 2026 – Prime Minister Gaston Browne has secured a historic fourth consecutive term in office, leading the Antigua and Barbuda Labour Party to a commanding victory in the country’s snap general election held April 30, 2026.

Preliminary results show Browne’s party capturing 15 of the 17 seats in Parliament, tightening its grip on power and dramatically weakening the opposition.

The main opposition United Progressive Party was reduced to just one seat, held by its leader, while the Barbuda People’s Movement retained its single constituency in Barbuda.

The result marks a major political turnaround for Browne, whose party had won a much narrower 9–7 majority in the 2023 election before rebuilding support through defections and by-elections.

Voter turnout figures vary in early reports, with initial estimates indicating participation of around 35.8 percent, or roughly 22,700 voters out of more than 63,000 registered. However, broader election data suggests overall turnout may have exceeded 60 percent, reflecting steady engagement despite political tensions.

The election, called nearly two years ahead of schedule, was shaped by concerns over the cost of living, global economic pressures and fallout from U.S. visa restrictions linked to the country’s citizenship-by-investment programme.

Despite those issues, Browne campaigned on economic stability and continued development, pointing to a strong tourism recovery and ongoing infrastructure expansion.

The decisive victory now strengthens his mandate, but also raises questions about the future of the opposition, which faces internal challenges after significant losses at the polls.

Angle by Deandrea Hamilton. Built with ChatGPT (AI). Magnetic Media — CAPTURING LIFE.

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Caribbean News

FIGHT FOR CONTROL OF STEWART TOURISM EMPIRE PLAYS OUT IN COURTS

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May 4, 2026 – This is not just a family dispute.  It is a fight over control of a tourism empire.

At the centre is Adam Stewart, who has secured a series of legal victories across the region as challenges continue over the estate and leadership structure of Sandals Resorts International.

The multi-billion-dollar conglomerate was built by the late Gordon “Butch” Stewart, whose passing in 2021 set off a complex and ongoing dispute involving family members, estate arrangements and control of the business.

In recent rulings, courts in both The Bahamas and Jamaica have reinforced Adam Stewart’s position, effectively allowing him to continue leading the company while defending his role against legal challenges.

One key issue has centred on the interpretation of estate provisions, including whether defending his leadership could jeopardise his inheritance. The courts have ruled in his favour, clearing the way for him to maintain control without penalty.

For now, those decisions bring a measure of stability to one of the Caribbean’s most influential tourism brands.

But the matter is far from settled.

Multiple legal challenges and competing claims within the Stewart family remain active, meaning the future structure of the company is still being contested.

The implications stretch well beyond the courtroom.

Sandals operates across several Caribbean nations, including The Bahamas, Turks and Caicos Islands, Jamaica and Saint Lucia, making it a critical player in regional tourism, employment and investment.

Any uncertainty at the top of the organisation has the potential to ripple across economies that rely heavily on the brand’s continued expansion and stability.

For now, Adam Stewart remains firmly in charge.  He was named Executive Chairman of Sandals Resorts International in 2021.

Still, many are keen on the outcomes of ongoing litigation, as the battle over one of the Caribbean’s most powerful business empires is still unfolding.

Angle by Deandrea Hamilton. Built with ChatGPT (AI). Magnetic Media — CAPTURING LIFE.

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