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Cleveland Clinic Announces Next Step in Preventive Breast Cancer Vaccine Study

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Clinical trial now studying cancer-free individuals at high risk for developing breast cancer

 

Cleveland Clinic researchers have launched the next step in their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

Funded by the U.S. Department of Defense, the new phase 1b study will enroll cancer-free individuals at high risk for developing breast cancer who have decided to voluntarily undergo prophylactic mastectomy to lower their risk.

Individuals in that category typically carry genetic mutations that put them at risk of developing triple-negative breast cancer or have high familial risk for any breast cancer. The study, conducted at Cleveland Clinic’s main campus, will evaluate safety and monitor immune response.

The new study will include approximately 6-12 patients and is anticipated to be complete by the end of 2023. Study participants will receive three vaccinations given two weeks apart and will be closely monitored for side effects and immune response.

The phase 1b clinical trial, conducted in partnership with Anixa Biosciences, Inc., follows the ongoing phase 1a study, which opened in 2021 and is expected to be complete in the  4th quarter of 2023. The phase 1a trial includes patients who completed treatment for early-stage, triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence.

“Triple-negative breast cancer is the form of the disease for which we have the least effective treatments,” said G. Thomas Budd, M.D., of Cleveland Clinic’s Taussig Cancer Institute and principal investigator of the study. “Long term, we are hoping that this can be a true preventive vaccine that would be administered to cancer-free individuals to prevent them from developing this highly aggressive disease.”

According to Dr. Budd, there is a great need for improved treatments for triple-negative breast cancer, which does not have biological characteristics that typically respond to hormonal or targeted therapies. Despite representing only about 12% to 15% of all breast cancers, triple-negative breast cancer accounts for a disproportionately higher percentage of breast cancer deaths. It is twice as likely to occur in Black women, and approximately 70 to 80% of the breast tumors that occur in women with mutations in the BRCA1 gene are triple-negative breast cancer.

The vaccine is based on pre-clinical research led by the late Vincent Tuohy, Ph.D., who was the Mort and Iris November Distinguished Chair in Innovative Breast Cancer Research at Cleveland Clinic’s Lerner Research Institute. Dr. Tuohy was an outstanding and passionate scientist and his decades of groundbreaking research led to the development of this investigational vaccine.

The vaccine targets a lactation protein, α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in the majority of triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing.

The study is based on Dr. Tuohy’s research that showed that activating the immune system against α-lactalbumin was safe and effective in preventing breast tumors in mice. The research, originally published in Nature Medicine, was funded in part by philanthropic gifts from more than 20,000 people over the last 12 years.

“It was Dr. Tuohy’s hope that this vaccine would demonstrate the potential of immunization as a new way to control breast cancer, and that a similar approach could someday be applied to other types of malignancy,” added Dr. Budd.

For more information and eligibility requirements visit clinicaltrials.gov.

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Caribbean News

Local Beauty Queen, Activist and Model Selena Grant Graces the May Cover of Vigor Magazine

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Turks & Caicos’ rising star continues to blaze trails on the global stage

Providenciales, TCI – Turks & Caicos native Selena Grant, 24, is making headlines once again—this time as the cover star for the April 2025 issue of Vigor Magazine, an international publication celebrated for spotlighting fashion, culture, and emerging talent from around the world.

Grant, who first captured national attention in May 2024 when she was crowned Miss One Nation TCI, has since built a reputation as one of the country’s most multifaceted young women. In the past year alone, she has claimed 1st Runner-Up titles in both the Miss Universe Turks & Caicos pageant and the international Miss Global International competition. Her success on the runway, however, is only part of her story.

A dedicated community activist, Selena has contributed to humanitarian causes across the Islands, working with organizations such as United Way and Edward C Garland Yoith Centre and other outreach efforts. She also lends her skills to the medical field, currently serving as a lab apprentice at InterHealth Canada Turks and Caicos Islands.

Now, as the face of Turks & Caicos Fashion Week 2025, Selena is once again flying the national flag high. But this cover moment is not hers alone—it’s a shared triumph with the renowned model , runway coach, designer and photographer Kaye Cox, who not only photographed but also styled, directed, and retouched the entire shoot.

“I was incredibly honored to work with Kaye on this project,” Selena shared. “She’s a creative powerhouse and visionary. From concept to execution, every detail was hers—and I’m just so proud we could bring this vision to life together.”

Shot on the iconic shores of Providenciales, the editorial captures the essence of island elegance with a bold, high-fashion twist. The visuals, rich with cultural pride and artistic depth, immediately caught the eye of Vigor editors and landed both women their well-deserved spot on the cover.

This feature is another major milestone in Selena’s journey and a celebration of the brilliant women behind the lens and in front of it.

This marks yet another milestone in Selena’s modeling career and underscores her continued role as a cultural ambassador for the Turks & Caicos Islands.

From the stage to the studio, from the lab to the pages of an international magazine, Selena Grant continues to prove that beauty, brains, and purpose can go hand in hand—with women like Kaye Cox right there capturing it all.

Congratulations, Selena !

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Bahamas News

Bahamian Archivist Antoinette Seymour Preserves Cultural Heritage with New Book “Been to Cat Island”

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The Bahamas, April 25, 2025 – Bahamian archivist and international chess legend Antoinette Seymour has undertaken the significant endeavor of archiving the rich cultural history of the Bahamas’ major islands. In her recent publication, “Been to Cat Island”, the first title in the “Been to Bahamas” series published by Inspire Publishing (Bahamas) 2024, Seymour passionately explores this vital task.

For many, the prospect of documenting the complexities of island history could seem daunting. However, Ms. Seymour, inspired by the strategic teachings of her late father, renowned chess master Warren Seymour, embraces the challenge. “Archivists preserve and safeguard culture, history, heritage, identity, legacy, and memory,” she asserts, referencing a 1996 UNESCO publication that states, “The loss of archives is as serious as the loss of memory in a human being.”

“Throughout my life, I have heard fascinating stories about Cat Island and from Cat Islanders—stories that deserve safeguarding,” Ms. Seymour emphasizes. “If these narratives are not preserved, they will tragically vanish.”

In “Been to Cat Island,” readers can explore the unique identity of Cat Island through Seymour’s passionate lens. Discover the origins of icons like Sir Sidney Poitier, encounter delightful anecdotes such as pigs feasting on lobster, and revel in the island’s rolling hills, pristine beaches, and vibrant heritage. This book is not merely a historical account; it is an intimate portrayal of resilience, culture, and connection.

While holding a critical archival position at her alma mater, the University of Windsor in Ontario, Canada, Ms. Seymour remains devoted to her Bahamian roots. She aims to ensure that current and future generations of Bahamians cherish our nation’s rich history. When not archiving, Ms. Seymour travels throughout the island and shares her expertise in chess with children across The Bahamas. She is a proud mother of two and a grandmother of one.

“Been to Cat Island” is available now at Chapter One bookstore, Logos Bookstore, Cia Monet, select museums in The Bahamas and bookstores in Canada, and on Amazon.com in both paperback and eBook formats.

 

 

For media inquiries, please contact:

Antoinette Seymour

Author Email: antoinetteseymour@yahoo.com

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Caribbean News

‘People will face consequences’ – VP Jagdeo on Adrianna Younge’s death

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Guyana, April 25, 2025 – As the nation mourns the heartbreaking death of 11-year-old Adrianna Younge, Vice President Dr Bharrat Jagdeo has expressed condolences to her family on behalf of the People’s Progressive Party (PPP) and called for full transparency in the ongoing probe.

During a press conference on Thursday, the Vice President described it as a “sad day for Guyana.”

He also made it clear that anyone within the Guyana Police Force (GPF) found to be involved in covering up the circumstances surrounding the child’s death will face severe consequences.

Dr. Jagdeo’s remarks come amid growing public outrage and scrutiny of the police’s handling of the case. He pointed to several troubling inconsistencies in the GPF’s initial report.

According to that report, Adrianna was at the swimming pool of the Double Day Hotel in Tuschen, East Bank Essequibo, with her grandmother and siblings when she reportedly disappeared around 13:00-14:00 hours. The police initially claimed that the hotel’s CCTV system was non-functional; however, footage from external sources reportedly captured Adrianna entering a red and black Toyota Raum, bearing registration number PSS 4684, which was later seen heading east toward Vreed-en-Hoop.

“If they have that footage (the police) and they put it in the statement…they should immediately release that footage,” Dr Jagdeo said.

“Something is wrong, and we have to get to the bottom of it. We are not going to rest until that happens. And whoever is culpable, whoever, if there is a coverup, people will face consequences; we are not going to tolerate this. This young girl should never have lost her life.”

Just 24 hours after issuing the initial report, the GPF acknowledged discrepancies in the information released and has since launched an internal review.

Dr Jagdeo also spoke of the emotional toll the incident has taken on Adrianna’s family, stating, “I saw a video of the father speaking and how distraught he was. The family deserves answers, and the people of this country need answers.”

The discovery of Adrianna’s body in the hotel pool after hours of desperate searching has plunged the nation into deep mourning. Frustration over handling the case has sparked protests, with citizens demanding justice and accountability.

President Dr Mohamed Irfaan Ali has since ordered the GPF to establish a special investigative team to uncover the full circumstances surrounding the child’s death.

“We must uncover the full truth of everything that transpired, and no resource or effort will be spared,” the President said via his official social media account.

President Ali also spoke directly with Adrianna’s mother, pledging the government’s full support in pursuing justice. President Ali has further instructed the GPF to compile a comprehensive report detailing all actions since the investigation began.

To support this, the government has ordered an independent autopsy and Barbadian forensic pathologist Dr. Shubhakar Karra Paul is expected to arrive in Guyana at 5:30 p.m. today to conduct the post-mortem examination.

VP Jagdeo also offered his condolences on behalf of the PPP to the families of Maline LaCruz, who was killed by her husband, along with her mother, Waveny LaCruz and sister, Sueann LaCruz. Maline’s younger brother, Ceon LaCruz, was also injured in the shooting and is in critical condition.

He said the government is committed to uncovering the details behind the shooting, particularly the legality of the gun used to kill the three women.

“Because if he had a legal firearm, after the assault, he was supposed to lodge the firearm … we will look at this matter,” he assured.

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