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Cleveland Clinic Announces Next Step in Preventive Breast Cancer Vaccine Study

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Clinical trial now studying cancer-free individuals at high risk for developing breast cancer

 

Cleveland Clinic researchers have launched the next step in their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

Funded by the U.S. Department of Defense, the new phase 1b study will enroll cancer-free individuals at high risk for developing breast cancer who have decided to voluntarily undergo prophylactic mastectomy to lower their risk.

Individuals in that category typically carry genetic mutations that put them at risk of developing triple-negative breast cancer or have high familial risk for any breast cancer. The study, conducted at Cleveland Clinic’s main campus, will evaluate safety and monitor immune response.

The new study will include approximately 6-12 patients and is anticipated to be complete by the end of 2023. Study participants will receive three vaccinations given two weeks apart and will be closely monitored for side effects and immune response.

The phase 1b clinical trial, conducted in partnership with Anixa Biosciences, Inc., follows the ongoing phase 1a study, which opened in 2021 and is expected to be complete in the  4th quarter of 2023. The phase 1a trial includes patients who completed treatment for early-stage, triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence.

“Triple-negative breast cancer is the form of the disease for which we have the least effective treatments,” said G. Thomas Budd, M.D., of Cleveland Clinic’s Taussig Cancer Institute and principal investigator of the study. “Long term, we are hoping that this can be a true preventive vaccine that would be administered to cancer-free individuals to prevent them from developing this highly aggressive disease.”

According to Dr. Budd, there is a great need for improved treatments for triple-negative breast cancer, which does not have biological characteristics that typically respond to hormonal or targeted therapies. Despite representing only about 12% to 15% of all breast cancers, triple-negative breast cancer accounts for a disproportionately higher percentage of breast cancer deaths. It is twice as likely to occur in Black women, and approximately 70 to 80% of the breast tumors that occur in women with mutations in the BRCA1 gene are triple-negative breast cancer.

The vaccine is based on pre-clinical research led by the late Vincent Tuohy, Ph.D., who was the Mort and Iris November Distinguished Chair in Innovative Breast Cancer Research at Cleveland Clinic’s Lerner Research Institute. Dr. Tuohy was an outstanding and passionate scientist and his decades of groundbreaking research led to the development of this investigational vaccine.

The vaccine targets a lactation protein, α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in the majority of triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing.

The study is based on Dr. Tuohy’s research that showed that activating the immune system against α-lactalbumin was safe and effective in preventing breast tumors in mice. The research, originally published in Nature Medicine, was funded in part by philanthropic gifts from more than 20,000 people over the last 12 years.

“It was Dr. Tuohy’s hope that this vaccine would demonstrate the potential of immunization as a new way to control breast cancer, and that a similar approach could someday be applied to other types of malignancy,” added Dr. Budd.

For more information and eligibility requirements visit clinicaltrials.gov.

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CHTA President Praises Jamaica’s Hurricane Preparedness, Assures Ongoing Support

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KINGSTON, Jamaica– President of the Caribbean Hotel and Tourism Association (CHTA), Nicola Madden-Greig, has praised the strength of local and regional public-private sector partnerships, while congratulating tourism stakeholders across Jamaica for their strong level of preparedness in weathering the dangerous Category 4 Hurricane Beryl, which impacted the island this week.

“Jamaica was spared the worst of the hurricane and we have now returned to regular business operations,” said Madden-Greig, who rode out the storm at her office in Kingston. She reported that Sangster International Airport in Montego Bay and Ian Fleming International Airport in Ocho Rios opened today, while Norman Manley International Airport in Kingston will open on Friday, July 5, after minor repairs are completed.

“We have no reports of any guests being injured during the passage of the storm, and the majority of the hotels and the tourism industry in general have emerged unscathed,” Madden-Greig added.

However, she expressed concerns for the south coast of the island, where many local communities were impacted, along with several independent hotels and villa operations.

“We will be including these operators in our disaster relief efforts, particularly in the Treasure Beach, St. Elizabeth area,” she noted, explaining however that she had little doubt that this resilient community will rebound in the shortest possible time.

The trade association leader was encouraged with the reports emanating from the Cayman Islands, which confirmed no major impact on the sector there. “We are thankful to God for sparing us for the most part, and we are now resolved to getting our industry back on track, while serving communities (especially those in the Grenadines) who are in dire need at this time,” said Madden-Greig.

Individuals, businesses and organizations that want to contribute to regional hurricane relief efforts may make a monetary donation at www.chtaef.com.

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CARICOM raising profile and priority of its Migration Policy; curbing challenges ‘a tall order’

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Garfield Ekon

Staff Writer

 

The Caribbean Community (CARICOM) is committed to work with Member States and other stakeholders to implement a “forward-thinking regional migration policy,” according to its Assistant Secretary General, Alison Drayton.

Addressing the opening of a recent three-day workshop titled “Towards a Regional Approach to a Migration Policy in the Caribbean,” in Port-of-Spain, Trinidad and Tobago, she said it is evident that the Region has been facing, and will continue to face, various challenges that affect the lives and livelihoods of Caribbean citizens.

“Namely, due to Climate Change, which has amplified displacements and the need for persons to migrate from areas that threaten their livelihoods or limit their opportunities to prosper and provide for their families,” the ASG told the forum, adding that the Climate Change and natural disasters remain “key drivers of displacements in the Region.”

“With the frequency and magnitude of events likely to increase in the future, this has contributed to many regional States facing demographic decline, which has impacted their workforce, our younger population seeking job opportunities outside the Region, and many key sectors being negatively impacted,” she stated.

The CARICOM official underscored that tackling the challenges would be “a tall order,” hence the Regional body’s commitment that would help address various aspects of Regional migration and human mobility as determined by Member State priorities.

Lauding the Government of Trinidad and Tobago for hosting the workshop, and the and valuable technical contributions made by the United Nations (UN) Migration Group and financial contributions from the United States Department of State, the European Union, and the Inter-American Development Bank, she said  the their efforts have been significant.

The contribution made by International Organization for Migration (IOM), has advanced the policy, with provision of consultancies to coordinate the Community’s work through the Regional Approach to Migration Policy (RAMP) Steering Committee and development of the framework, she highlighted.

For Trinidad and Tobago’s National Security Minister, the Hon. Fitzgerald Hinds, his country is also committed to contributing to the development of a regional migration policy framework that reflects the priorities of the people of the Caribbean Community.

“As we embark on this journey together, let us harness the expertise, the insights and the experiences that we already have among us as we gather here today to shape the policy framework that is in front of us,” the Minister said, adding that the current migration realities “should prepare us for future challenges.”

The technical workshop brought together National Focal Points from the CARICOM Member States, and representatives of relevant regional and international organisations, building on IOM’s Migration Governance Indicator (MGI) assessments, and other consultations held with national Governments of CARICOM Member States in 2023.

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Government Earmarks $300M for Post-Hurricane Dengue Mitigation

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#Kingston, Jamaica, July 19, 2024 – The Government has earmarked $300 million to ramp up dengue mitigation activities, inclusive of fogging, treatment of mosquito breeding sites, removal of bulky waste and drain cleaning, in the aftermath of Hurricane Beryl.

Addressing the House of Representatives on Tuesday (July 16), Prime Minister, the Most Hon. Andrew Holness, said the funds have been allocated to the Ministry of Health and Wellness, which will spearhead vector-control activities over the next six weeks.

He further informed that the National Solid Waste Management Authority (NSWMA) and National Works Agency (NWA), “are technically involved in this dengue mitigation [exercise] by trying to clear the environmental conditions that would create the growth in the vector”.

Mr. Holness highlighted the potential for a significant increase in the dengue vector, the Aedes aegpyti mosquito, which breeds primarily in containers, consequent on  the hurricane’s passage.

“We know that many communities are being plagued by the increase in the mosquito population… and other vectors [such as] roaches, rats and flies. Therefore, the cleanup and removal and clearing of waterlogged areas is of critical importance,” he emphasised.

The Prime Minister noted that the hot summer conditions, along with rainfall, will further contribute to heightening the possibility of an increase in these vectors and the transmission of diseases.

As such, he appealed to Jamaicans to properly store water in covered containers and destroy mosquito breeding sites around their homes.

“I urge all homeowners who are storing water and… leaving the containers open, that an easy way to control the growth of the mosquito population in your households is to cover the containers,” Mr. Holness said.

He pointed out that the NSWMA will shortly announce a schedule for the removal of bulky waste from homes.

Prime Minister Holness further indicated that the NWA will be actively cleaning various gullies.

Dengue symptoms include fever, headache, and joint and muscle pains. These are often resolved through rest and adequate hydration along with the use of paracetamol to treat the accompanying fever.

 

Contact: Chris Patterson

Release: JIS

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