Caribbean News
Cleveland Clinic Announces Next Step in Preventive Breast Cancer Vaccine Study
Clinical trial now studying cancer-free individuals at high risk for developing breast cancer
Cleveland Clinic researchers have launched the next step in their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.
Funded by the U.S. Department of Defense, the new phase 1b study will enroll cancer-free individuals at high risk for developing breast cancer who have decided to voluntarily undergo prophylactic mastectomy to lower their risk.
Individuals in that category typically carry genetic mutations that put them at risk of developing triple-negative breast cancer or have high familial risk for any breast cancer. The study, conducted at Cleveland Clinic’s main campus, will evaluate safety and monitor immune response.
The new study will include approximately 6-12 patients and is anticipated to be complete by the end of 2023. Study participants will receive three vaccinations given two weeks apart and will be closely monitored for side effects and immune response.
The phase 1b clinical trial, conducted in partnership with Anixa Biosciences, Inc., follows the ongoing phase 1a study, which opened in 2021 and is expected to be complete in the 4th quarter of 2023. The phase 1a trial includes patients
who completed treatment for early-stage, triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence.
“Triple-negative breast cancer is the form of the disease for which we have the least effective treatments,” said G. Thomas Budd, M.D., of Cleveland Clinic’s Taussig Cancer Institute and principal investigator of the study. “Long term, we are hoping that this can be a true preventive vaccine that would be administered to cancer-free individuals to prevent them from developing this highly aggressive disease.”
According to Dr. Budd, there is a great need for improved treatments for triple-negative breast cancer, which does not have biological characteristics that typically respond to hormonal or targeted therapies. Despite representing only about 12% to 15% of all breast cancers, triple-negative breast cancer accounts for a disproportionately higher percentage of breast cancer deaths. It is twice as likely to occur in Black women, and approximately 70 to 80% of the breast tumors that occur in women with mutations in the BRCA1 gene are triple-negative breast cancer.
The vaccine is based on pre-clinical research led by the late Vincent Tuohy, Ph.D., who was the Mort and Iris November Distinguished Chair in Innovative Breast Cancer Research at Cleveland Clinic’s Lerner Research Institute. Dr. Tuohy was an outstanding and passionate scientist and his decades of groundbreaking research led to the development of this investigational vaccine.
The vaccine targets a lactation protein, α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in the majority of triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing.
The study is based on Dr. Tuohy’s research that showed that activating the immune system against α-lactalbumin was safe and effective in preventing breast tumors in mice. The research, originally published in Nature Medicine, was funded in part by philanthropic gifts from more than 20,000 people over the last 12 years.
“It was Dr. Tuohy’s hope that this vaccine would demonstrate the potential of immunization as a new way to control breast cancer, and that a similar approach could someday be applied to other types of malignancy,” added Dr. Budd.
For more information and eligibility requirements visit clinicaltrials.gov.
KINGSTON, May 1 (JIS):
Ground has been broken at the tuition-free Christel House at Twickenham Park, St. Catherine, for the construction of a high school.
Minister of Education and Youth, Hon. Faval Williams, who delivered the keynote address at the site, today (May 1), said Christel House’s dedication to breaking the cycle of poverty and empowering vulnerable children is “nothing short of inspiring”.
“Your decision to invest in Jamaica speaks volumes about your belief in our nation’s potential, and your dedication to making a meaningful difference in the lives of our youth is appreciated,” Minister Williams said.
She added that the partnership between the Government and the organisation, forged through a Memorandum of Understanding (MOU) in 2019, is a “prime example” of what can be achieved when public and private entities come together with a shared vision and purpose.
Further, the Minister said a foundation is being laid for a brighter future, one where every child has the opportunity to thrive and fulfil their potential, regardless of their circumstances.
She said that Christel House Jamaica, which now operates a kindergarten school at the location, will in time be more than just a school.
“It will be a symbol of optimism, a sanctuary of learning, and a catalyst for positive change in our community,” the Minister said.
“By providing comprehensive support, including education, nutrition, healthcare, and mentorship, Christel House will empower students to break free from the chains of poverty and chart a course towards a better tomorrow,” she added.
Mrs. Willliams said the shared goal between the Administration and Christel House extends beyond the construction of a building, as it is about nurturing the next generation of leaders, innovators, and change-makers who will shape the destiny of the nation.
“Together, we are sowing the seeds of prosperity, equity, and social justice, ensuring that no child is left behind,” she said.
The school provides breakfast, lunch and an afternoon snack, as well as transportation for children living far distances from the school. It also provides uniforms and textbooks, and counselling services for its students who have to contend with psychological and other emotional issues.
Founder of Christel House International, Christel Dehaan, emigrated from Germany to the United States (US) in 1962, and was an accomplished businesswoman.
In 1996, she sold her global enterprise, Resort Condominiums International (RCI), which had offices in 38 countries, and devoted her resources to philanthropic work from her headquarters in North Meridian Street, Indianapolis.
With support from dedicated donors, schools are run in India, Jamaica, Mexico, South Africa, and the US.
CONTACT: GARFIELD L. ANGUS
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