Health
Cleveland Clinic: First Patient to Receive Breast Cancer Vaccine Shares Health Journey
The vaccine targets a lactation protein called α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in most triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing. (Courtesy: Cleveland Clinic)
#USA, April 17, 2023 – During a typical day at work, Jennifer Davis received an unexpected call that changed her life. A nurse on the other end of the line delivered the news Jennifer had triple-negative breast cancer. The mother of three recalls feeling terrified. She didn’t know how she was going to tell her family. After receiving the diagnosis, Jennifer knew she wanted to take advantage of every treatment option available. Through her driven search for answers, she became the first person to participate in a novel study at Cleveland Clinic for a vaccine that aims to eventually prevent triple-negative breast cancer.
“When I found out I was the first person to receive the vaccine, I was excited. I was thrilled. The trial has given me a lot of hope,” says Jennifer, a registered nurse from Lisbon, Ohio.
Jennifer’s health journey started in February 2018 when she felt a lump in her breast. She went to a local hospital for follow-up, and her first biopsy showed no evidence of cancer. Months went by, and Jennifer says the lump grew. She listened to her body and continued to get it checked. Jennifer eventually received another biopsy after doctors detected abnormalities during an ultrasound. Her diagnosis was confirmed about one week later, and she sought a second opinion for her treatment.
“I knew I wanted to go to Cleveland Clinic, so I had my first appointment there shortly after. I met my entire care team within my first few appointments and had a complete treatment plan. I was very happy with my team and was anxious to get started,” says Jennifer.
As part of the plan, she underwent multiple rounds of chemotherapy and radiation. She also had a double mastectomy performed by breast surgeon Zahraa AlHilli, MD.
“After the double mastectomy, I was adamant while in recovery about wanting to know what they found and whether the cancer had spread. Dr. AlHilli was able to get clear margins, and there were no signs the cancer had spread anywhere else,” says Jennifer.
After undergoing treatment, it was during her follow-up appointments with breast medical oncologist Megan Kruse, MD, she learned about the breast cancer vaccine clinical trial.
The vaccine is based on pre-clinical research led by the late Vincent Tuohy, PhD, who was the Mort and Iris November Distinguished Chair in Innovative Breast Cancer Research at Cleveland Clinic’s Lerner Research Institute. The vaccine targets a lactation protein called α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in most triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing.
Research nurse coordinator Donna Lach administers the third dose of the breast cancer vaccine to Jennifer. (Courtesy: Cleveland Clinic)
“Triple-negative breast cancer is the form of the disease for which we have the least effective treatments,” said G. Thomas Budd, MD, breast medical oncologist and principal investigator for the breast cancer vaccine trial. “Long term, we are hoping this can be a true preventive vaccine that would be administered to cancer-free individuals to prevent them from developing this highly aggressive disease.”
Jennifer is involved in phase 1a of the study, which includes patients who completed treatment for early-stage, triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence.
“There is no medication I take to make sure there’s not a recurrence,” says Jennifer. “With every ache and pain, your mind goes to the worst-case scenario. So, I was very excited when I heard about the vaccine.”
In October 2021, Jennifer became the first patient to enroll in the trial and receive the first dose of the vaccine. “I didn’t think twice about getting the vaccine and haven’t looked back since.”
Dr. Kruse says, “For a long time with triple-negative breast cancer, the overarching theme patients talked about is how they’re going through all this treatment but still feeling like they’re destined to have the cancer return. I think having the hope of this vaccine study where we can potentially turn that around and have some optimism as we approach the future for these patients is the best part.”
Over the course of the study, Jennifer and other participants received three doses of the vaccine. The vaccinations were each given two weeks apart, and the participants were closely monitored for side effects and immune response. She received her last dose in November 2021 and has not noted any major side effects.
“My husband went with me for the first vaccine. Then my mom went with me for the second and third,” says Jennifer. “I don’t know if I ever went to an appointment at Cleveland Clinic by myself, and that support has meant a lot to me.”
Jennifer is hopeful about the vaccine trial and encourages others to stay positive amid the ongoing research. (Courtesy: Cleveland Clinic)
In February 2023, Cleveland Clinic researchers launched the next step in their study of the vaccine. The phase 1b clinical trial, conducted in partnership with Anixa Biosciences, Inc., focuses on individuals who are cancer-free, at high risk for developing breast cancer and have decided to voluntarily undergo a prophylactic mastectomy to lower their risk.
Meanwhile, Jennifer, now 46 years old, continues to follow up with Dr. Kruse as she nears her fifth year of being in remission. Although it will take years to fully understand the vaccine’s effectiveness, she’s eager for what’s to come and hopes her story can help others diagnosed with breast cancer.
“Even though you’re going to have days where you’re not positive, where you feel terrible – keep moving forward. If the vaccine works the way they want, it could prevent triple-negative breast cancer one day,” says Jennifer.
Editor’s note: Dr. Tuohy was inventor of the technology, which Cleveland Clinic exclusively licensed to Anixa Biosciences. He was entitled to a portion of the commercialization revenues received by Cleveland Clinic and also held equity in the company.
Related Institutes: Lerner Research Institute, Cleveland Clinic Cancer Center
Deandrea Hamilton | Editor
Turks and Caicos, September 6, 2025 – COVID-19 fears in the Turks and Caicos Islands that once had residents on edge are now giving way to a sense of relief. The Ministry of Health and Human Services reports a dramatic reversal: from dozens of new cases in July to zero cases and zero hospitalizations today.
Between August 17 and 23, 2025, officials confirmed no new cases, no hospitalizations, and no new deaths. Just two recoveries were recorded, bringing the national recovery tally to 6,866. The total confirmed cases since 2020 stand at 6,922, with deaths unchanged at 41. Health officials say August has been relatively quiet overall, with 19 new cases and recoveries recorded for the month — a fraction of what the islands faced just weeks earlier.
The contrast could not be sharper. The most concerning bulletin came in mid-July, when the Ministry reported 54 new cases in a single
week. Ten were fresh positives, while the other 44 came from a backlog of April samples. At that time, two new hospitalizations were recorded, and the islands mourned one additional COVID-related death, bringing the total to 41. It was a sobering reminder that the virus was still circulating, pushing recoveries to 6,845 and raising the cumulative case count to 6,910. The July spike stirred fear among residents and renewed calls for vigilance, as community spread and delayed lab results painted a worrying picture.
Fast forward to late August, and the numbers tell a very different story. Not only are new cases negligible, but the hospitals are reporting no COVID-19 patients at all. Officials say testing continues across a wide range of categories, and the Ministry urges the public to stay cautious: wash hands, wear masks in crowded spaces, protect the vulnerable, and get vaccinated. But the tone now is one of optimism.
Since the pandemic began in 2020, Turks and Caicos has recorded nearly 7,000 cases in total, with 6,866 recoveries and 41 deaths. The islands’ small population means every case has felt significant, and surges like July’s were especially unsettling. But today’s figures suggest the country has reached a new stage: COVID-19 is no longer the disruptive force it was. The Ministry credits continued public vigilance and the accessibility of free testing and vaccines at government clinics. While the numbers are cause for celebration, health leaders are careful not to declare the fight over. The Ministry’s latest bulletin reminds residents to maintain hygienic practices, follow self-isolation guidelines if infected, and ensure vaccinations are up to date.
The pandemic may not be entirely behind the Turks and Caicos, but compared to the frightening figures of July, the near-zero landscape of August offers a powerful sign of hope.
The Ministry released the bulletin on September 2, confirming that for the week of August 17–23, no new cases, hospitalizations, or deaths were recorded — a sharp contrast to the surge just weeks earlier.
Health
Turks and Caicos Islands Health Delegation Completes Strategic Visits to Florida and Cayman Islands to Advance Health Sector Reform and Strengthen Treatment Abroad Programme
Providenciales, Turks and Caicos Islands, 22 August 2025 — A high-level delegation from the Ministry of Health and Human Services (MOHHS) has successfully concluded strategic working visits to Florida and the Cayman Islands from August 5–13, 2025. The mission aimed to strengthen the Treatment Abroad Programme, explore innovative health system models, and advance the Turks and Caicos Islands’ health sector reform agenda through strategic regional partnerships.
Delegation Members:
- Hon. Kyle Knowles – Minister of Health and Human Services
MoHHS Team with Health City Executive Management Team
- Mrs. Desiree Lewis – Permanent Secretary, Health and Human Services
- Mr. Lynrod Brooks – Director, Health Policy and Planning
- Ms. Florinda Talbot – Contract Performance Manager
- Mrs. Romaine Missick-Smith – CEO, Health Regulations Authority
- Ms. Jasmine Malcolm – Executive Administrator, MOHHS
Minister of Health and Human Services, Hon. Kyle Knowles, highlighted the significance of these engagements:
“These visits were not ceremonial; they were strategic, focused, and impactful. In Florida, we reinforced partnerships with leading healthcare providers to ensure TCI patients referred overseas receive the highest standards of clinical care and patient support. In the Cayman Islands, our mission was two-fold: to study the operations of the Cayman Islands Health Services Authority as a model to guide the establishment of our own Health Services Authority, and to strengthen ties with Cayman-based treatment partners, where many of our patients are referred under the Treatment Abroad Programme. Both visits underscored that small island states share many health challenges, and that collaboration, innovation, and adapting best practices to our local context are essential to achieving better health outcomes for our people.”
Florida – Strengthening the Treatment Abroad Programme
MoHHS Team with Cayman Minsterial officials
During the period August 5–9, the delegation visited Broward Medical Center, University of Miami Health System, Cleveland Clinic, Nicklaus Children’s Hospital, and the International Reinsurance Managers Network. They also toured REVA Air Ambulance Services to review medical evacuation operations and patient transfer management. Discussions centered on patient care pathways, specialized services in ophthalmology, cardiology, oncology, and pediatrics, family-centered care models, advanced telemedicine for pre- and post-treatment consultations, and reinsurance strategies for high-cost overseas cases. Key outcomes include agreements to expand telehealth consultations, develop a standardized referral package to reduce delays, explore reinsurance arrangements to safeguard public health budgets, and establish specialized pediatric transfer protocols.
Cayman Islands – Health Sector Reform and Treatment Abroad Partnerships
From August 10–13, the delegation engaged with senior executives at Health City Cayman Islands, including Dr. Binoy Chattuparambil (Clinical Director), Shomari Scott (Chief Business Development Officer), Rebecca Brooks (Head of Marketing and Sales), and Ingrid Harris (Sales and Marketing). The team toured two hospital facilities and held in-depth discussions with Lizzette Yearwood, Chief Executive Officer along with leadership staff of the Cayman Islands Health Services Authority
The focus was two-fold:
- Health Sector Reform – Examining governance, financial management, and operational structures of the Cayman Islands HSA model
MoHHS Team with CEO and senior official Cayman HSA
to inform TCI’s development of its own Health Services Authority.
- Treatment Abroad Strengthening – Reviewing current referral arrangements with Cayman healthcare partners to enhance patient care coordination and improve treatment pathways for TCI patients referred to Cayman.
The delegation also met with Honourable Katherine Ebanks-Wilks, Minister for Health, Environment, Sustainability, and Honourable G. Wayne Panton, Parliamentary Secretary for Health. The team concluded with a meeting with Acting Premier Hon. Gary B. Rutty and Cabinet members, reaffirming the shared commitment to improving healthcare access and outcomes through regional collaboration.
Next Steps
The Ministry will incorporate lessons learned from these visits into ongoing health reform planning, ensuring that the proposed Health Services Authority is tailored to TCI’s needs while reflecting regional best practices. Efforts will continue to ensure that the Treatment Abroad Programme delivers efficient, sustainable, and patient-centered care.
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