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Cleveland Clinic: First Patient to Receive Breast Cancer Vaccine Shares Health Journey

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The vaccine targets a lactation protein called α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in most triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing. (Courtesy: Cleveland Clinic)

#USA, April 17, 2023 – During a typical day at work, Jennifer Davis received an unexpected call that changed her life. A nurse on the other end of the line delivered the news Jennifer had triple-negative breast cancer. The mother of three recalls feeling terrified. She didn’t know how she was going to tell her family. After receiving the diagnosis, Jennifer knew she wanted to take advantage of every treatment option available. Through her driven search for answers, she became the first person to participate in a novel study at Cleveland Clinic for a vaccine that aims to eventually prevent triple-negative breast cancer.

“When I found out I was the first person to receive the vaccine, I was excited. I was thrilled. The trial has given me a lot of hope,” says Jennifer, a registered nurse from Lisbon, Ohio.  

Jennifer’s health journey started in February 2018 when she felt a lump in her breast. She went to a local hospital for follow-up, and her first biopsy showed no evidence of cancer. Months went by, and Jennifer says the lump grew. She listened to her body and continued to get it checked. Jennifer eventually received another biopsy after doctors detected abnormalities during an ultrasound. Her diagnosis was confirmed about one week later, and she sought a second opinion for her treatment.  

“I knew I wanted to go to Cleveland Clinic, so I had my first appointment there shortly after. I met my entire care team within my first few appointments and had a complete treatment plan. I was very happy with my team and was anxious to get started,” says Jennifer.  

As part of the plan, she underwent multiple rounds of chemotherapy and radiation. She also had a double mastectomy performed by breast surgeon Zahraa AlHilli, MD.  

“After the double mastectomy, I was adamant while in recovery about wanting to know what they found and whether the cancer had spread. Dr. AlHilli was able to get clear margins, and there were no signs the cancer had spread anywhere else,” says Jennifer.  

After undergoing treatment, it was during her follow-up appointments with breast medical oncologist Megan Kruse, MD, she learned about the breast cancer vaccine clinical trial.  

The vaccine is based on pre-clinical research led by the late Vincent Tuohy, PhD, who was the Mort and Iris November Distinguished Chair in Innovative Breast Cancer Research at Cleveland Clinic’s Lerner Research Institute. The vaccine targets a lactation protein called α-lactalbumin, which is no longer found after lactation in normal, aging tissues but is present in most triple-negative breast cancers. If breast cancer develops, the vaccine is designed to prompt the immune system to attack the tumor and keep it from growing.  

Research nurse coordinator Donna Lach administers the third dose of the breast cancer vaccine to Jennifer. (Courtesy: Cleveland Clinic)

“Triple-negative breast cancer is the form of the disease for which we have the least effective treatments,” said G. Thomas Budd, MD, breast medical oncologist and principal investigator for the breast cancer vaccine trial. “Long term, we are hoping this can be a true preventive vaccine that would be administered to cancer-free individuals to prevent them from developing this highly aggressive disease.”  

Jennifer is involved in phase 1a of the study, which includes patients who completed treatment for early-stage, triple-negative breast cancer within the past three years and are currently tumor-free but at high risk for recurrence.  

“There is no medication I take to make sure there’s not a recurrence,” says Jennifer. “With every ache and pain, your mind goes to the worst-case scenario. So, I was very excited when I heard about the vaccine.”  

In October 2021, Jennifer became the first patient to enroll in the trial and receive the first dose of the vaccine. “I didn’t think twice about getting the vaccine and haven’t looked back since.”  

Dr. Kruse says, “For a long time with triple-negative breast cancer, the overarching theme patients talked about is how they’re going through all this treatment but still feeling like they’re destined to have the cancer return. I think having the hope of this vaccine study where we can potentially turn that around and have some optimism as we approach the future for these patients is the best part.”  

Over the course of the study, Jennifer and other participants received three doses of the vaccine. The vaccinations were each given two weeks apart, and the participants were closely monitored for side effects and immune response. She received her last dose in November 2021 and has not noted any major side effects.  

“My husband went with me for the first vaccine. Then my mom went with me for the second and third,” says Jennifer. “I don’t know if I ever went to an appointment at Cleveland Clinic by myself, and that support has meant a lot to me.”  

Jennifer is hopeful about the vaccine trial and encourages others to stay positive amid the ongoing research. (Courtesy: Cleveland Clinic)

In February 2023, Cleveland Clinic researchers launched the next step in their study of the vaccine. The phase 1b clinical trial, conducted in partnership with Anixa Biosciences, Inc., focuses on individuals who are cancer-free, at high risk for developing breast cancer and have decided to voluntarily undergo a prophylactic mastectomy to lower their risk.  

Meanwhile, Jennifer, now 46 years old, continues to follow up with Dr. Kruse as she nears her fifth year of being in remission. Although it will take years to fully understand the vaccine’s effectiveness, she’s eager for what’s to come and hopes her story can help others diagnosed with breast cancer.  

“Even though you’re going to have days where you’re not positive, where you feel terrible – keep moving forward. If the vaccine works the way they want, it could prevent triple-negative breast cancer one day,” says Jennifer.  

Editor’s note: Dr. Tuohy was inventor of the technology, which Cleveland Clinic exclusively licensed to Anixa Biosciences. He was entitled to a portion of the commercialization revenues received by Cleveland Clinic and also held equity in the company.

Related Institutes: Lerner Research InstituteCleveland Clinic Cancer Center

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Turks and Caicos Islands Hospital Celebrates Patient Safety Awareness Month: “Team Up for Patient Safety”

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Turks and Caicos Islands – March 23, 2026 – In recognition of Patient Safety Awareness Week, observed March 8–14, 2026, the Turks and Caicos Islands Hospital, operated by InterHealth Canada Ltd., proudly joined healthcare partners worldwide in advancing this year’s theme, “Team Up for Patient Safety.” The 2026 campaign emphasized the critical role of teamwork and reinforced the importance of collaboration among patients, families, care teams, and leadership in creating safer healthcare environments.

While globally observed as a week-long initiative, the Turks and Caicos Islands Hospital extended its activities throughout the entire month of March, underscoring that patient safety requires sustained commitment, continuous learning, and shared accountability.

A Month of Learning, Engagement, and Collaboration

Throughout March, the hospital hosted a series of Continuing Professional Education (CPE) sessions aimed at strengthening competencies and reinforcing a culture of safety across all levels of care. These included:

  • Patient SafetyYour Role, empowering individuals to recognize and act on their impact on safety outcomes
  • Effective Communication Strategies, focusing on delivering safe care through structured, reliable communication
  • TeamSTEPPS – Reinforcement and Expansion, strengthening the use of evidence based teamwork tools to enhance care delivery

Grand Rounds sessions further supported clinical excellence and knowledge translation, featuring:

  • Rescue Ready 2025: Translating AHA PALS Updates into Practice
  • Colorectal Cancer Screening: A Roadmap for Caribbean Countries
  • Beyond the Algorithm: Applying the latest American heart Association BLS & ACLS Guidance in Emergency Practice

To promote engagement and learning in an interactive format, a Patient Safety Trivia Event was also hosted. The event featured five dynamic rounds covering patient safety principles, general knowledge, and a TCI knowledge lightning round, with prizes awarded to the top five participants. In addition, we welcomed Grade 4 students to our Hospital Teddy Bear Clinic, which served as an innovative extension of our patient safety efforts. This initiative allowed children to role-play as caregivers by bringing their teddy bears for “treatment,” helping them understand basic healthcare processes such as first aid, hand hygiene, communication, and safe care practices. By introducing these concepts early, the clinic not only reduces fear associated with healthcare settings but also promotes awareness of patient safety behaviours in a simple, memorable way.

Reaffirming a Shared Commitment

A defining moment of the month was the symbolic passing of the Patient Safety Baton, reinforcing the collective responsibility for safe care:

“Patient safety is not one person’s responsibility. It is a commitment we share across teams, departments, organizations, and nations; and it is upheld in partnership with every patient and family we serve.”

Advancing the 2026 Patient Safety Objectives

Aligned with the global theme, the hospital’s initiatives focused on four strategic priorities:

  • Promote Collaboration: Encouraging active participation from all members of the care team, including patients and families
  • Enhance Communication: Strengthening open dialogue to improve understanding of care plans and safety protocols
  • Recognize Achievements: Celebrating progress while identifying opportunities for continuous improvement
  • Engage Communities: Inspiring broader discussions on patient safety, equity, and quality in healthcare delivery

Acknowledgements

The Board of Directors and Executive Leadership of the Turks and Caicos Islands Hospital extend sincere appreciation to all who participated in the month’s activities and contributed to the success and sustainability of this important initiative.

Special thanks are extended to our dedicated healthcare teams for their unwavering commitment to delivering safe, high-quality care; our video and production team for effectively amplifying key messages; our valued healthcare partners for their collaboration and support; and the leadership of the Turks and Caicos Islands, including Her Excellency the Governor, Dileeni Daniel-Selvaratnam, the Honourable Premier, Charles Washington Misick and the Honourable Minister of Health, Kyle Knowles for their continued guidance and commitment to advancing patient safety nationally.

Building a Culture That Lasts

“Patient safety is not a solo effort, it is a collective commitment that defines the integrity of our healthcare system,” said Isha Honoré, Quality, Risk, Patient Safety and Management Lead at the Turks and Caicos Islands Hospital. “Our responsibility is to design and sustain environments where teams are supported, patients are heard, and risks are proactively managed. Through sustained engagement beyond this month, we are advancing a culture of high reliability, where safety is consistently delivered, measured, and continuously improved.”

Dr. Denise Braithwaite-Tennant, Chief Executive Officer of the Turks and Caicos Islands Hospital, reaffirmed the organization’s commitment, noting that patient safety remains central to the hospital’s mission and strategic direction. “Patient safety is at the heart of everything we do. This year’s theme, ‘Team Up for Patient Safety,’ reinforces a simple but powerful truth, safe care is achieved when we work together. At the Turks and Caicos Islands Hospital, we are committed to fostering a culture where collaboration, communication, and accountability guide every interaction. I am proud of our teams for their dedication throughout this month and beyond, as we continue to strengthen systems, empower our staff and patients, and deliver care that is consistently safe, reliable, and of high quality.”

The Turks and Caicos Islands Hospital remains dedicated to fostering a culture where safety is prioritized, communication is strengthened, and every voice, staff, patient, and family, is valued.

Healthcare professionals, community partners, patients, and families are encouraged to continue supporting patient safety by speaking up, staying informed, and working collaboratively to improve care outcomes.

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Turks and Caicos Islands Medical Association (TCIMA) Elects New Executive

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Turks and Caicos, March 23, 2026 – The Turks and Caicos Islands Medical Association (TCIMA) held its 2026 General Meeting and Elections on Saturday March 21st 2026 at the Hamilton Education Foundation Conference Center in Grace Bay, Providenciales.

Outgoing Acting President Dr. Jameiko Harvey, welcomed physician and dental attendees present both in person and virtually from across the Turks and Caicos Islands to the gathering.  Following introductions of the outgoing executives: Dr. Dawn Perry-Ewing(Secretary), Dr. Marcella Malcolm (Treasurer), Dr. Denise Braithwaite Tennant (Public Relations and Training Officer); Dr. Darren Hall (Immediate Past President) was invited to address the gathering and spoke of the significant role the organization played in the development of healthcare in the Turks and Caicos Islands over the years.  In his delivery, Dr. Hall recognized the contributions of Dr. Ken Peterson, TCIMA’s first President and founding member, who held the office for several years.  Hon. Dr. Rufus Ewing, also a founding member of the Association, addressed the group, sharing the history of the organization and issued the charge for members to actively participate in the organization to the betterment, not only of its membership, but also to the greater good of the community.

The Turks And Caicos Islands Medical Association (TCIMA), is registered as a Non-Profit Organization company under the Turks and Caicos Islands Companies Ordinance with membership consisting of Physicians and Dentists permanently resident and registered in the Turks and Caicos Islands. Included amongst the objects of the Association are:

  • The promotion of the health sciences and the better health of individuals and the communities in which they live.
  • The promotion of the interests of the medical profession and especially to secure the conditions which will make it possible for them to render to their society the best professional services possible.
  • To obtain for the medical profession the opportunity to participate actively at all levels in the formulation of national medical health policies in The Turks and Caicos Islands.

Following the election, the members of the Association welcomed the new executive team consisting of: Dr. Francois Bourne as President, Dr. Susan Delpeche as Vice President, Dr. Dawn Perry-Ewing as Secretary, Dr. Marcela Malcolm as Treasurer, Dr. Karlansia Mills as Public Relations Officer and Dr. Joanna Bowden as Education Officer, who will serve in these positions for a period of two years.

Incoming President Dr. Francois Bourne addressed the gathering outlining plans to engage with the membership across all islands, establish transparent processes and urged members to build an organization that they are proud of and that represents them.  Medical practitioners ordinarily resident in The Turks and Caicos Islands and registered and licensed under the Turks and Caicos Islands Health Professions Ordinance 2016 are eligible to become a Member of the Association.  Applications are accepted via the Association’s website – https://www.tcimedicalassociation.org/membership

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Gut Health Linked to Lower Colorectal Cancer Risk According to Cleveland Clinic Dietitian

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March 19, 2026 – March is Colorectal Cancer Awareness Month, a time dedicated to highlighting the importance of prevention and early detection of one of the most common cancers affecting both men and women, according to the CDC.

March is Colorectal Cancer Awareness Month and according to the CDC, colorectal cancer is the third most common cancer for both men and women.

The good news is there are ways to help prevent it, like improving your gut health.

“A healthy gut and a diverse microbiome help decrease inflammation, and chronic inflammation we know can lead to increased risk of cancer, specifically colorectal cancer,” explained Julia Zumpano, RD, registered dietitian at Cleveland Clinic.

Zumpano said we can help improve our gut health by improving our diet.

She recommends eating foods that are high in fiber, such as whole grains, fruits, vegetables, legumes, nuts and seeds.

She also suggests adding fermented and probiotic foods into your diet. Some ideas include yogurt, kefir, kimchi and sauerkraut.

Zumpano notes that it can be overwhelming to eat a bunch of new foods at once, which is why it’s best to make a gradual transition.

“I would first begin by reducing processed foods and incorporating more fiber rich foods. And you’ll see your gut symptoms improve. So, if you have any symptoms like constipation or diarrhea, those things should improve. Now if you’re finding that you’re having gastrointestinal symptoms that aren’t going away despite making positive health changes, that’s when you should seek medical attention,” she advised.

Besides keeping a healthy diet, Zumpano said it’s also important to make sure you’re getting enough physical activity as exercise has been shown to help reduce a person’s risk for colorectal cancer.

By focusing on small sustainable lifestyle changes such as eating a fiber-rich diet, supporting gut health and staying physically active, people can take meaningful steps toward lowering the risk of colorectal cancer and improving their overall health.

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